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Defective hydrophobic sliding mechanism and active site expansion in HIV-1 protease drug resistant variant Gly48Thr/Leu89Met: mechanisms for the loss of saquinavir binding potency.
Goldfarb NE, Ohanessian M, Biswas S, McGee TD Jr, Mahon BP, Ostrov DA, Garcia J, Tang Y, McKenna R, Roitberg A, Dunn BM. Goldfarb NE, et al. Among authors: mckenna r. Biochemistry. 2015 Jan 20;54(2):422-33. doi: 10.1021/bi501088e. Epub 2015 Jan 7. Biochemistry. 2015. PMID: 25513833 Free PMC article.
Targeting carbonic anhydrase IX activity and expression.
Mahon BP, Pinard MA, McKenna R. Mahon BP, et al. Among authors: mckenna r. Molecules. 2015 Jan 30;20(2):2323-48. doi: 10.3390/molecules20022323. Molecules. 2015. PMID: 25647573 Free PMC article. Review.
Structural and biophysical characterization of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2: insights into engineering thermostable enzymes for CO2 sequestration.
Díaz-Torres NA, Mahon BP, Boone CD, Pinard MA, Tu C, Ng R, Agbandje-McKenna M, Silverman D, Scott K, McKenna R. Díaz-Torres NA, et al. Among authors: mckenna r. Acta Crystallogr D Biol Crystallogr. 2015 Aug;71(Pt 8):1745-56. doi: 10.1107/S1399004715012183. Epub 2015 Jul 31. Acta Crystallogr D Biol Crystallogr. 2015. PMID: 26249355 Free PMC article.
962 results