Poutiainen P - Search Results

1

Re-exploring the N-phenylpicolinamide derivatives to develop mGlu4 ligands with improved affinity and in vitro microsomal stability.

Zhang Z, Kil KE, Poutiainen P, Choi JK, Kang HJ, Huang XP, Roth BL, Brownell AL. Zhang Z, et al. Among authors: poutiainen p. Bioorg Med Chem Lett. 2015 Sep 15;25(18):3956-60. doi: 10.1016/j.bmcl.2015.07.031. Epub 2015 Jul 17. Bioorg Med Chem Lett. 2015. PMID: 26231155 Free PMC article.

2

Radiosynthesis and evaluation of an 18F-labeled positron emission tomography (PET) radioligand for metabotropic glutamate receptor subtype 4 (mGlu4).

Kil KE, Poutiainen P, Zhang Z, Zhu A, Choi JK, Jokivarsi K, Brownell AL. Kil KE, et al. Among authors: poutiainen p. J Med Chem. 2014 Nov 13;57(21):9130-8. doi: 10.1021/jm501245b. Epub 2014 Oct 27. J Med Chem. 2014. PMID: 25330258 Free PMC article.

3

Co-operative binding assay for the characterization of mGlu4 allosteric modulators.

Poutiainen P, Kil KE, Zhang Z, Kuruppu D, Tannous B, Brownell AL. Poutiainen P, et al. Neuropharmacology. 2015 Oct;97:142-8. doi: 10.1016/j.neuropharm.2015.05.017. Epub 2015 May 27. Neuropharmacology. 2015. PMID: 26025660 Free PMC article.

4

Functional modulation of G-protein coupled receptors during Parkinson disease-like neurodegeneration.

Jenkins BG, Zhu A, Poutiainen P, Choi JK, Kil KE, Zhang Z, Kuruppu D, Aytan N, Dedeoglu A, Brownell AL. Jenkins BG, et al. Among authors: poutiainen p. Neuropharmacology. 2016 Sep;108:462-73. doi: 10.1016/j.neuropharm.2015.11.010. Epub 2015 Nov 12. Neuropharmacology. 2016. PMID: 26581500 Free PMC article.

5

Synthesis and evaluation of N-(methylthiophenyl)picolinamide derivatives as PET radioligands for metabotropic glutamate receptor subtype 4.

Kil KE, Poutiainen P, Zhang Z, Zhu A, Kuruppu D, Prabhakar S, Choi JK, Tannous BA, Brownell AL. Kil KE, et al. Among authors: poutiainen p. Bioorg Med Chem Lett. 2016 Jan 1;26(1):133-9. doi: 10.1016/j.bmcl.2015.11.015. Epub 2015 Nov 10. Bioorg Med Chem Lett. 2016. PMID: 26602273 Free PMC article.

6

Synthesis and Characterization of Fluorine-18-Labeled N-(4-Chloro-3-((fluoromethyl-d₂)thio)phenyl)picolinamide for Imaging of mGluR4 in Brain.

Wang J, Qu X, Shoup TM, Yuan G, Afshar S, Pan C, Zhu A, Choi JK, Kang HJ, Poutiainen P, El Fakhri G, Zhang Z, Brownell AL. Wang J, et al. Among authors: poutiainen p. J Med Chem. 2020 Mar 26;63(6):3381-3389. doi: 10.1021/acs.jmedchem.0c00201. Epub 2020 Mar 4. J Med Chem. 2020. PMID: 32081008 Free PMC article.

7

Design, Synthesis, and Characterization of Benzimidazole Derivatives as Positron Emission Tomography Imaging Ligands for Metabotropic Glutamate Receptor 2.

Yuan G, Qu X, Zheng B, Neelamegam R, Afshar S, Iyengar S, Pan C, Wang J, Kang HJ, Ondrechen MJ, Poutiainen P, El Fakhri G, Zhang Z, Brownell AL. Yuan G, et al. Among authors: poutiainen p. J Med Chem. 2020 Oct 22;63(20):12060-12072. doi: 10.1021/acs.jmedchem.0c01394. Epub 2020 Oct 7. J Med Chem. 2020. PMID: 32981322 Free PMC article.

8

Loss of Metabotropic Glutamate Receptor 5 Function on Peripheral Benzodiazepine Receptor in Mice Prenatally Exposed to LPS.

Arsenault D, Coulombe K, Zhu A, Gong C, Kil KE, Choi JK, Poutiainen P, Brownell AL. Arsenault D, et al. Among authors: poutiainen p. PLoS One. 2015 Nov 4;10(11):e0142093. doi: 10.1371/journal.pone.0142093. eCollection 2015. PLoS One. 2015. PMID: 26536027 Free PMC article.

9

PET imaging studies show enhanced expression of mGluR5 and inflammatory response during progressive degeneration in ALS mouse model expressing SOD1-G93A gene.

Brownell AL, Kuruppu D, Kil KE, Jokivarsi K, Poutiainen P, Zhu A, Maxwell M. Brownell AL, et al. Among authors: poutiainen p. J Neuroinflammation. 2015 Nov 24;12:217. doi: 10.1186/s12974-015-0439-9. J Neuroinflammation. 2015. PMID: 26597638 Free PMC article.

10

Precision Medicine in Multiple Sclerosis: Future of PET Imaging of Inflammation and Reactive Astrocytes.

Poutiainen P, Jaronen M, Quintana FJ, Brownell AL. Poutiainen P, et al. Front Mol Neurosci. 2016 Sep 15;9:85. doi: 10.3389/fnmol.2016.00085. eCollection 2016. Front Mol Neurosci. 2016. PMID: 27695400 Free PMC article. Review.

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