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The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes.
Teka IA, Kazibwe AJ, El-Sabbagh N, Al-Salabi MI, Ward CP, Eze AA, Munday JC, Mäser P, Matovu E, Barrett MP, de Koning HP. Teka IA, et al. Among authors: de koning hp. Mol Pharmacol. 2011 Jul;80(1):110-6. doi: 10.1124/mol.111.071555. Epub 2011 Mar 24. Mol Pharmacol. 2011. PMID: 21436312 Free PMC article.
In and out of the minor groove: interaction of an AT-rich DNA with the drug CD27.
Acosta-Reyes FJ, Dardonville C, de Koning HP, Natto M, Subirana JA, Campos JL. Acosta-Reyes FJ, et al. Among authors: de koning hp. Acta Crystallogr D Biol Crystallogr. 2014 Jun;70(Pt 6):1614-21. doi: 10.1107/S139900471400697X. Epub 2014 May 24. Acta Crystallogr D Biol Crystallogr. 2014. PMID: 24914972 Free PMC article.
A new nonpolar N-hydroxy imidazoline lead compound with improved activity in a murine model of late-stage Trypanosoma brucei brucei infection is not cross-resistant with diamidines.
Ríos Martínez CH, Miller F, Ganeshamoorthy K, Glacial F, Kaiser M, de Koning HP, Eze AA, Lagartera L, Herraiz T, Dardonville C. Ríos Martínez CH, et al. Among authors: de koning hp. Antimicrob Agents Chemother. 2015 Feb;59(2):890-904. doi: 10.1128/AAC.03958-14. Epub 2014 Nov 24. Antimicrob Agents Chemother. 2015. PMID: 25421467 Free PMC article.
186 results