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Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C-H Functionalization.
Lowell AN, DeMars MD 2nd, Slocum ST, Yu F, Anand K, Chemler JA, Korakavi N, Priessnitz JK, Park SR, Koch AA, Schultz PJ, Sherman DH. Lowell AN, et al. Among authors: park sr. J Am Chem Soc. 2017 Jun 14;139(23):7913-7920. doi: 10.1021/jacs.7b02875. Epub 2017 Jun 5. J Am Chem Soc. 2017. PMID: 28525276 Free PMC article.
Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.
Mo S, Kim DH, Lee JH, Park JW, Basnet DB, Ban YH, Yoo YJ, Chen SW, Park SR, Choi EA, Kim E, Jin YY, Lee SK, Park JY, Liu Y, Lee MO, Lee KS, Kim SJ, Kim D, Park BC, Lee SG, Kwon HJ, Suh JW, Moore BS, Lim SK, Yoon YJ. Mo S, et al. Among authors: park bc, park sr, park jy, park jw. J Am Chem Soc. 2011 Feb 2;133(4):976-85. doi: 10.1021/ja108399b. Epub 2010 Dec 22. J Am Chem Soc. 2011. PMID: 21175203 Free PMC article.
725 results