Hansen DA - Search Results

1

Evolution of Efficient Modular Polyketide Synthases by Homologous Recombination.

Chemler JA, Tripathi A, Hansen DA, O'Neil-Johnson M, Williams RB, Starks C, Park SR, Sherman DH. Chemler JA, et al. Among authors: hansen da. J Am Chem Soc. 2015 Aug 26;137(33):10603-9. doi: 10.1021/jacs.5b04842. Epub 2015 Aug 13. J Am Chem Soc. 2015. PMID: 26230368 Free PMC article.

2

Biocatalytic synthesis of pikromycin, methymycin, neomethymycin, novamethymycin, and ketomethymycin.

Hansen DA, Rath CM, Eisman EB, Narayan AR, Kittendorf JD, Mortison JD, Yoon YJ, Sherman DH. Hansen DA, et al. J Am Chem Soc. 2013 Jul 31;135(30):11232-8. doi: 10.1021/ja404134f. Epub 2013 Jul 18. J Am Chem Soc. 2013. PMID: 23866020 Free PMC article.

3

Cyanobacterial polyketide synthase docking domains: a tool for engineering natural product biosynthesis.

Whicher JR, Smaga SS, Hansen DA, Brown WC, Gerwick WH, Sherman DH, Smith JL. Whicher JR, et al. Among authors: hansen da. Chem Biol. 2013 Nov 21;20(11):1340-51. doi: 10.1016/j.chembiol.2013.09.015. Epub 2013 Oct 31. Chem Biol. 2013. PMID: 24183970 Free PMC article.

4

Directing group-controlled regioselectivity in an enzymatic C-H bond oxygenation.

Negretti S, Narayan AR, Chiou KC, Kells PM, Stachowski JL, Hansen DA, Podust LM, Montgomery J, Sherman DH. Negretti S, et al. Among authors: hansen da. J Am Chem Soc. 2014 Apr 2;136(13):4901-4. doi: 10.1021/ja5016052. Epub 2014 Mar 21. J Am Chem Soc. 2014. PMID: 24627965 Free PMC article.

5

Structure of a modular polyketide synthase.

Dutta S, Whicher JR, Hansen DA, Hale WA, Chemler JA, Congdon GR, Narayan AR, Håkansson K, Sherman DH, Smith JL, Skiniotis G. Dutta S, et al. Among authors: hansen da. Nature. 2014 Jun 26;510(7506):512-7. doi: 10.1038/nature13423. Epub 2014 Jun 18. Nature. 2014. PMID: 24965652 Free PMC article.

6

Structural rearrangements of a polyketide synthase module during its catalytic cycle.

Whicher JR, Dutta S, Hansen DA, Hale WA, Chemler JA, Dosey AM, Narayan AR, Håkansson K, Sherman DH, Smith JL, Skiniotis G. Whicher JR, et al. Among authors: hansen da. Nature. 2014 Jun 26;510(7506):560-4. doi: 10.1038/nature13409. Epub 2014 Jun 18. Nature. 2014. PMID: 24965656 Free PMC article.

7

Substrate controlled divergence in polyketide synthase catalysis.

Hansen DA, Koch AA, Sherman DH. Hansen DA, et al. J Am Chem Soc. 2015 Mar 25;137(11):3735-8. doi: 10.1021/ja511743n. Epub 2015 Mar 12. J Am Chem Soc. 2015. PMID: 25730816 Free PMC article.

8

Resistance to ketolide antibiotics by coordinated expression of rRNA methyltransferases in a bacterial producer of natural ketolides.

Almutairi MM, Park SR, Rose S, Hansen DA, Vázquez-Laslop N, Douthwaite S, Sherman DH, Mankin AS. Almutairi MM, et al. Among authors: hansen da. Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):12956-61. doi: 10.1073/pnas.1512090112. Epub 2015 Oct 5. Proc Natl Acad Sci U S A. 2015. PMID: 26438831 Free PMC article.

9

Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering.

Koryakina I, Kasey C, McArthur JB, Lowell AN, Chemler JA, Li S, Hansen DA, Sherman DH, Williams GJ. Koryakina I, et al. Among authors: hansen da. ACS Chem Biol. 2017 Jan 20;12(1):114-123. doi: 10.1021/acschembio.6b00732. Epub 2016 Nov 29. ACS Chem Biol. 2017. PMID: 28103677 Free PMC article.

10

A Single Active Site Mutation in the Pikromycin Thioesterase Generates a More Effective Macrocyclization Catalyst.

Koch AA, Hansen DA, Shende VV, Furan LR, Houk KN, Jiménez-Osés G, Sherman DH. Koch AA, et al. Among authors: hansen da. J Am Chem Soc. 2017 Sep 27;139(38):13456-13465. doi: 10.1021/jacs.7b06436. Epub 2017 Sep 19. J Am Chem Soc. 2017. PMID: 28836768 Free PMC article.

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