Li J - Search Results

1

Scaffold Diversity Inspired by the Natural Product Evodiamine: Discovery of Highly Potent and Multitargeting Antitumor Agents.

Wang S, Fang K, Dong G, Chen S, Liu N, Miao Z, Yao J, Li J, Zhang W, Sheng C. Wang S, et al. Among authors: li j. J Med Chem. 2015 Aug 27;58(16):6678-96. doi: 10.1021/acs.jmedchem.5b00910. Epub 2015 Aug 19. J Med Chem. 2015. PMID: 26226379

2

Binding interaction of quercetin-3-beta-galactoside and its synthetic derivatives with SARS-CoV 3CL(pro): structure-activity relationship studies reveal salient pharmacophore features.

Chen L, Li J, Luo C, Liu H, Xu W, Chen G, Liew OW, Zhu W, Puah CM, Shen X, Jiang H. Chen L, et al. Among authors: li j. Bioorg Med Chem. 2006 Dec 15;14(24):8295-306. doi: 10.1016/j.bmc.2006.09.014. Epub 2006 Oct 12. Bioorg Med Chem. 2006. PMID: 17046271 Free PMC article.

3

Identification of novel falcipain-2 inhibitors as potential antimalarial agents through structure-based virtual screening.

Li H, Huang J, Chen L, Liu X, Chen T, Zhu J, Lu W, Shen X, Li J, Hilgenfeld R, Jiang H. Li H, et al. Among authors: li j. J Med Chem. 2009 Aug 13;52(15):4936-40. doi: 10.1021/jm801622x. J Med Chem. 2009. PMID: 19586036

4

Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.

Ni S, Yuan Y, Huang J, Mao X, Lv M, Zhu J, Shen X, Pei J, Lai L, Jiang H, Li J. Ni S, et al. Among authors: li j. J Med Chem. 2009 Sep 10;52(17):5295-8. doi: 10.1021/jm9008295. J Med Chem. 2009. PMID: 19691347

5

Design and synthesis of small molecule RhoA inhibitors: a new promising therapy for cardiovascular diseases?

Deng J, Feng E, Ma S, Zhang Y, Liu X, Li H, Huang H, Zhu J, Zhu W, Shen X, Miao L, Liu H, Jiang H, Li J. Deng J, et al. Among authors: li j, li h. J Med Chem. 2011 Jul 14;54(13):4508-22. doi: 10.1021/jm200161c. Epub 2011 Jun 7. J Med Chem. 2011. PMID: 21615130

6

Synthesis and anti-tumor activities of N'-benzylidene-2-(4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone derivatives.

Lou J, Liu Z, Li Y, Zhou M, Zhang Z, Zheng S, Wang R, Li J. Lou J, et al. Among authors: li y, li j. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6662-6. doi: 10.1016/j.bmcl.2011.09.061. Epub 2011 Sep 21. Bioorg Med Chem Lett. 2011. PMID: 21986587

7

Discovery of novel small molecule inhibitors of dengue viral NS2B-NS3 protease using virtual screening and scaffold hopping.

Deng J, Li N, Liu H, Zuo Z, Liew OW, Xu W, Chen G, Tong X, Tang W, Zhu J, Zuo J, Jiang H, Yang CG, Li J, Zhu W. Deng J, et al. Among authors: li j, li n. J Med Chem. 2012 Jul 26;55(14):6278-93. doi: 10.1021/jm300146f. Epub 2012 Jul 11. J Med Chem. 2012. PMID: 22742496

8

Discovery and optimization of 1,3,4-trisubstituted-pyrazolone derivatives as novel, potent, and nonsteroidal farnesoid X receptor (FXR) selective antagonists.

Huang H, Yu Y, Gao Z, Zhang Y, Li C, Xu X, Jin H, Yan W, Ma R, Zhu J, Shen X, Jiang H, Chen L, Li J. Huang H, et al. Among authors: li c, li j. J Med Chem. 2012 Aug 23;55(16):7037-53. doi: 10.1021/jm3002718. Epub 2012 Aug 10. J Med Chem. 2012. PMID: 22862148

9

Structure-based design and synthesis of C-1- and C-4-modified analogs of zanamivir as neuraminidase inhibitors.

Feng E, Shin WJ, Zhu X, Li J, Ye D, Wang J, Zheng M, Zuo JP, No KT, Liu X, Zhu W, Tang W, Seong BL, Jiang H, Liu H. Feng E, et al. Among authors: li j. J Med Chem. 2013 Feb 14;56(3):671-84. doi: 10.1021/jm3009713. Epub 2013 Jan 30. J Med Chem. 2013. PMID: 23330908

10

Fragment-based drug discovery of 2-thiazolidinones as inhibitors of the histone reader BRD4 bromodomain.

Zhao L, Cao D, Chen T, Wang Y, Miao Z, Xu Y, Chen W, Wang X, Li Y, Du Z, Xiong B, Li J, Xu C, Zhang N, He J, Shen J. Zhao L, et al. Among authors: li y, li j. J Med Chem. 2013 May 23;56(10):3833-51. doi: 10.1021/jm301793a. Epub 2013 May 14. J Med Chem. 2013. PMID: 23530754

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