Li G - Search Results

1

Discovery of a Teraryl Oxazolidinone Compound (S)-N-((3-(3-Fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide Phosphate as a Novel Antimicrobial Agent with Enhanced Safety Profile and Efficacies.

Yang T, Chen G, Sang Z, Liu Y, Yang X, Chang Y, Long H, Ang W, Tang J, Wang Z, Li G, Yang S, Zhang J, Wei Y, Luo Y. Yang T, et al. Among authors: li g. J Med Chem. 2015 Aug 27;58(16):6389-409. doi: 10.1021/acs.jmedchem.5b00152. Epub 2015 Aug 17. J Med Chem. 2015. PMID: 26212502

2

Discovery of novel mGluR1 antagonists: a multistep virtual screening approach based on an SVM model and a pharmacophore hypothesis significantly increases the hit rate and enrichment factor.

Li GB, Yang LL, Feng S, Zhou JP, Huang Q, Xie HZ, Li LL, Yang SY. Li GB, et al. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1736-40. doi: 10.1016/j.bmcl.2011.01.087. Epub 2011 Jan 25. Bioorg Med Chem Lett. 2011. PMID: 21316965

3

Discovery of N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit-to-lead optimization.

Yang LL, Li GB, Yan HX, Sun QZ, Ma S, Ji P, Wang ZR, Feng S, Zou J, Yang SY. Yang LL, et al. Eur J Med Chem. 2012 Oct;56:30-8. doi: 10.1016/j.ejmech.2012.08.007. Epub 2012 Aug 14. Eur J Med Chem. 2012. PMID: 22944772

4

Structure-activity relationship studies of pyrazolo[3,4-d]pyrimidine derivatives leading to the discovery of a novel multikinase inhibitor that potently inhibits FLT3 and VEGFR2 and evaluation of its activity against acute myeloid leukemia in vitro and in vivo.

Yang LL, Li GB, Ma S, Zou C, Zhou S, Sun QZ, Cheng C, Chen X, Wang LJ, Feng S, Li LL, Yang SY. Yang LL, et al. J Med Chem. 2013 Feb 28;56(4):1641-55. doi: 10.1021/jm301537p. Epub 2013 Feb 19. J Med Chem. 2013. PMID: 23362959

5

ID-Score: a new empirical scoring function based on a comprehensive set of descriptors related to protein-ligand interactions.

Li GB, Yang LL, Wang WJ, Li LL, Yang SY. Li GB, et al. J Chem Inf Model. 2013 Mar 25;53(3):592-600. doi: 10.1021/ci300493w. Epub 2013 Feb 26. J Chem Inf Model. 2013. PMID: 23394072

6

YL529, a novel, orally available multikinase inhibitor, potently inhibits angiogenesis and tumour growth in preclinical models.

Xu Y, Lin H, Meng N, Lu W, Li G, Han Y, Dai X, Xia Y, Song X, Yang S, Wei Y, Yu L, Zhao Y. Xu Y, et al. Among authors: li g. Br J Pharmacol. 2013 Aug;169(8):1766-80. doi: 10.1111/bph.12216. Br J Pharmacol. 2013. PMID: 23594209 Free PMC article.

7

SC-535, a novel oral multikinase inhibitor, showed potent antitumor activity in human melanoma models.

Chen X, Ji P, Yang HW, Yang LL, Zhou S, Zhong L, Ma S, Fu XY, Zhou C, Li GB, Zheng MW, Wei YQ, Yang SY. Chen X, et al. Cell Physiol Biochem. 2013;32(1):138-53. doi: 10.1159/000350123. Epub 2013 Jul 12. Cell Physiol Biochem. 2013. PMID: 23867251 Free article.

8

A combined molecular docking-based and pharmacophore-based target prediction strategy with a probabilistic fusion method for target ranking.

Li GB, Yang LL, Xu Y, Wang WJ, Li LL, Yang SY. Li GB, et al. J Mol Graph Model. 2013 Jul;44:278-85. doi: 10.1016/j.jmgm.2013.07.005. Epub 2013 Jul 23. J Mol Graph Model. 2013. PMID: 23933279

9

A prediction model of drug-induced ototoxicity developed by an optimal support vector machine (SVM) method.

Zhou S, Li GB, Huang LY, Xie HZ, Zhao YL, Chen YZ, Li LL, Yang SY. Zhou S, et al. Comput Biol Med. 2014 Aug;51:122-7. doi: 10.1016/j.compbiomed.2014.05.005. Epub 2014 May 17. Comput Biol Med. 2014. PMID: 24907415

10

YLT192, a novel, orally active bioavailable inhibitor of VEGFR2 signaling with potent antiangiogenic activity and antitumor efficacy in preclinical models.

Xia Y, Song X, Li D, Ye T, Xu Y, Lin H, Meng N, Li G, Deng S, Zhang S, Liu L, Zhu Y, Zeng J, Lei Q, Pan Y, Wei Y, Zhao Y, Yu L. Xia Y, et al. Among authors: li d, li g. Sci Rep. 2014 Aug 12;4:6031. doi: 10.1038/srep06031. Sci Rep. 2014. PMID: 25112436 Free PMC article.

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