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Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer.
Timsah Z, Ahmed Z, Ivan C, Berrout J, Gagea M, Zhou Y, Pena GN, Hu X, Vallien C, Kingsley CV, Lu Y, Hancock JF, Liu J, Gladden AB, Mills GB, Lopez-Berestein G, Hung MC, Sood AK, Bogdanov M, Ladbury JE. Timsah Z, et al. Among authors: liu j. Oncogene. 2016 Apr 28;35(17):2186-96. doi: 10.1038/onc.2015.279. Epub 2015 Jul 27. Oncogene. 2016. PMID: 26212011 Free PMC article.
Bcr phosphorylated on tyrosine 177 binds Grb2.
Ma G, Lu D, Wu Y, Liu J, Arlinghaus RB. Ma G, et al. Among authors: liu j. Oncogene. 1997 May 15;14(19):2367-72. doi: 10.1038/sj.onc.1201053. Oncogene. 1997. PMID: 9178913
Bcr: a negative regulator of the Bcr-Abl oncoprotein.
Wu Y, Ma G, Lu D, Lin F, Xu HJ, Liu J, Arlinghaus RB. Wu Y, et al. Among authors: liu j. Oncogene. 1999 Aug 5;18(31):4416-24. doi: 10.1038/sj.onc.1202828. Oncogene. 1999. PMID: 10442632
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