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Small lipidated anti-obesity compounds derived from neuromedin U.
Micewicz ED, Bahattab OS, Willars GB, Waring AJ, Navab M, Whitelegge JP, McBride WH, Ruchala P. Micewicz ED, et al. Eur J Med Chem. 2015 Aug 28;101:616-26. doi: 10.1016/j.ejmech.2015.07.020. Epub 2015 Jul 14. Eur J Med Chem. 2015. PMID: 26204509 Free PMC article.
Novel dimeric Smac analogs as prospective anticancer agents.
Micewicz ED, Luong HT, Jung CL, Waring AJ, McBride WH, Ruchala P. Micewicz ED, et al. Bioorg Med Chem Lett. 2014 Mar 15;24(6):1452-7. doi: 10.1016/j.bmcl.2014.02.024. Epub 2014 Feb 18. Bioorg Med Chem Lett. 2014. PMID: 24582479
Small cyclic agonists of iron regulatory hormone hepcidin.
Chua K, Fung E, Micewicz ED, Ganz T, Nemeth E, Ruchala P. Chua K, et al. Among authors: micewicz ed. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4961-4969. doi: 10.1016/j.bmcl.2015.03.012. Epub 2015 Mar 12. Bioorg Med Chem Lett. 2015. PMID: 25813158 Free PMC article.
Lipid-conjugated Smac analogues.
Micewicz ED, Ratikan JA, Waring AJ, Whitelegge JP, McBride WH, Ruchala P. Micewicz ED, et al. Bioorg Med Chem Lett. 2015 Oct 15;25(20):4419-27. doi: 10.1016/j.bmcl.2015.09.017. Epub 2015 Sep 8. Bioorg Med Chem Lett. 2015. PMID: 26384289 Free PMC article.
Position of lipidation influences anticancer activity of Smac analogs.
Micewicz ED, Nguyen C, Micewicz A, Waring AJ, McBride WH, Ruchala P. Micewicz ED, et al. Bioorg Med Chem Lett. 2019 Jul 1;29(13):1628-1635. doi: 10.1016/j.bmcl.2019.04.041. Epub 2019 Apr 26. Bioorg Med Chem Lett. 2019. PMID: 31047753 Free PMC article.
4-(Nitrophenylsulfonyl)piperazines mitigate radiation damage to multiple tissues.
Micewicz ED, Kim K, Iwamoto KS, Ratikan JA, Cheng G, Boxx GM, Damoiseaux RD, Whitelegge JP, Ruchala P, Nguyen C, Purbey P, Loo J, Deng G, Jung ME, Sayre JW, Norris AJ, Schaue D, McBride WH. Micewicz ED, et al. PLoS One. 2017 Jul 21;12(7):e0181577. doi: 10.1371/journal.pone.0181577. eCollection 2017. PLoS One. 2017. PMID: 28732024 Free PMC article.
27 results