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Page 1
Inactivation of the p53 pathway in retinoblastoma.
Laurie NA, Donovan SL, Shih CS, Zhang J, Mills N, Fuller C, Teunisse A, Lam S, Ramos Y, Mohan A, Johnson D, Wilson M, Rodriguez-Galindo C, Quarto M, Francoz S, Mendrysa SM, Guy RK, Marine JC, Jochemsen AG, Dyer MA. Laurie NA, et al. Among authors: guy rk. Nature. 2006 Nov 2;444(7115):61-6. doi: 10.1038/nature05194. Nature. 2006. PMID: 17080083
Identification and characterization of the first small molecule inhibitor of MDMX.
Reed D, Shen Y, Shelat AA, Arnold LA, Ferreira AM, Zhu F, Mills N, Smithson DC, Regni CA, Bashford D, Cicero SA, Schulman BA, Jochemsen AG, Guy RK, Dyer MA. Reed D, et al. Among authors: guy rk. J Biol Chem. 2010 Apr 2;285(14):10786-96. doi: 10.1074/jbc.M109.056747. Epub 2010 Jan 15. J Biol Chem. 2010. PMID: 20080970 Free PMC article.
Whole-body physiologically based pharmacokinetic model for nutlin-3a in mice after intravenous and oral administration.
Zhang F, Tagen M, Throm S, Mallari J, Miller L, Guy RK, Dyer MA, Williams RT, Roussel MF, Nemeth K, Zhu F, Zhang J, Lu M, Panetta JC, Boulos N, Stewart CF. Zhang F, et al. Among authors: guy rk. Drug Metab Dispos. 2011 Jan;39(1):15-21. doi: 10.1124/dmd.110.035915. Epub 2010 Oct 14. Drug Metab Dispos. 2011. PMID: 20947617 Free PMC article.
Optimization of propafenone analogues as antimalarial leads.
Lowes DJ, Guiguemde WA, Connelly MC, Zhu F, Sigal MS, Clark JA, Lemoff AS, Derisi JL, Wilson EB, Guy RK. Lowes DJ, et al. Among authors: guy rk. J Med Chem. 2011 Nov 10;54(21):7477-85. doi: 10.1021/jm2005546. Epub 2011 Oct 10. J Med Chem. 2011. PMID: 21955244 Free PMC article.
On the mechanism of action of SJ-172550 in inhibiting the interaction of MDM4 and p53.
Bista M, Smithson D, Pecak A, Salinas G, Pustelny K, Min J, Pirog A, Finch K, Zdzalik M, Waddell B, Wladyka B, Kedracka-Krok S, Dyer MA, Dubin G, Guy RK. Bista M, et al. Among authors: guy rk. PLoS One. 2012;7(6):e37518. doi: 10.1371/journal.pone.0037518. Epub 2012 Jun 4. PLoS One. 2012. PMID: 22675482 Free PMC article.
175 results