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Page 1
Targeting of eEF1A with Amaryllidaceae isocarbostyrils as a strategy to combat melanomas.
Van Goietsenoven G, Hutton J, Becker JP, Lallemand B, Robert F, Lefranc F, Pirker C, Vandenbussche G, Van Antwerpen P, Evidente A, Berger W, Prévost M, Pelletier J, Kiss R, Kinzy TG, Kornienko A, Mathieu V. Van Goietsenoven G, et al. Among authors: van antwerpen p. FASEB J. 2010 Nov;24(11):4575-84. doi: 10.1096/fj.10-162263. Epub 2010 Jul 19. FASEB J. 2010. PMID: 20643906 Free PMC article.
In vitro anticancer activity, toxicity and structure-activity relationships of phyllostictine A, a natural oxazatricycloalkenone produced by the fungus Phyllosticta cirsii.
Le Calvé B, Lallemand B, Perrone C, Lenglet G, Depauw S, Van Goietsenoven G, Bury M, Vurro M, Herphelin F, Andolfi A, Zonno MC, Mathieu V, Dufrasne F, Van Antwerpen P, Poumay Y, David-Cordonnier MH, Evidente A, Kiss R. Le Calvé B, et al. Among authors: van antwerpen p, van goietsenoven g. Toxicol Appl Pharmacol. 2011 Jul 1;254(1):8-17. doi: 10.1016/j.taap.2011.03.027. Epub 2011 Apr 12. Toxicol Appl Pharmacol. 2011. PMID: 21504755
4-Bromo-2-(piperidin-1-yl)thiazol-5-yl-phenyl methanone (12b) inhibits Na+/K(+)-ATPase and Ras oncogene activity in cancer cells.
Lefranc F, Xu Z, Burth P, Mathieu V, Revelant G, de Castro Faria MV, Noyon C, Garcia DG, Dufour D, Bruyère C, Gonçalves-de-Albuquerque CF, Van Antwerpen P, Rogister B, Hesse S, Kirsch G, Kiss R. Lefranc F, et al. Among authors: van antwerpen p. Eur J Med Chem. 2013 May;63:213-23. doi: 10.1016/j.ejmech.2013.01.046. Epub 2013 Feb 16. Eur J Med Chem. 2013. PMID: 23474907
Design, synthesis, and structure-activity relationship studies of novel 3-alkylindole derivatives as selective and highly potent myeloperoxidase inhibitors.
Soubhye J, Aldib I, Elfving B, Gelbcke M, Furtmüller PG, Podrecca M, Conotte R, Colet JM, Rousseau A, Reye F, Sarakbi A, Vanhaeverbeek M, Kauffmann JM, Obinger C, Nève J, Prévost M, Zouaoui Boudjeltia K, Dufrasne F, Van Antwerpen P. Soubhye J, et al. Among authors: van antwerpen p. J Med Chem. 2013 May 23;56(10):3943-58. doi: 10.1021/jm4001538. Epub 2013 May 6. J Med Chem. 2013. PMID: 23581551
Ophiobolin A, a sesterterpenoid fungal phytotoxin, displays higher in vitro growth-inhibitory effects in mammalian than in plant cells and displays in vivo antitumor activity.
Bury M, Novo-Uzal E, Andolfi A, Cimini S, Wauthoz N, Heffeter P, Lallemand B, Avolio F, Delporte C, Cimmino A, Dubois J, Van Antwerpen P, Zonno MC, Vurro M, Poumay Y, Berger W, Evidente A, De Gara L, Kiss R, Locato V. Bury M, et al. Among authors: van antwerpen p. Int J Oncol. 2013 Aug;43(2):575-85. doi: 10.3892/ijo.2013.1979. Epub 2013 Jun 10. Int J Oncol. 2013. PMID: 23754298
Hybrid molecules inhibiting myeloperoxidase activity and serotonin reuptake: a possible new approach of major depressive disorders with inflammatory syndrome.
Soubhye J, Aldib I, Prévost M, Elfving B, Gelbcke M, Podrecca M, Conotte R, Colet JM, Furtmüller PG, Delporte C, Rousseau A, Vanhaeverbeek M, Nève J, Obinger C, Zouaoui-Boudjeltia K, Van Antwerpen P, Dufrasne F. Soubhye J, et al. Among authors: van antwerpen p. J Pharm Pharmacol. 2014 Aug;66(8):1122-32. doi: 10.1111/jphp.12236. Epub 2014 Mar 27. J Pharm Pharmacol. 2014. PMID: 24673477
Novel bis-arylalkylamines as myeloperoxidase inhibitors: Design, synthesis, and structure-activity relationship study.
Aldib I, Gelbcke M, Soubhye J, Prévost M, Furtmüller PG, Obinger C, Elfving B, Alard IC, Roos G, Delporte C, Berger G, Dufour D, Zouaoui Boudjeltia K, Nève J, Dufrasne F, Van Antwerpen P. Aldib I, et al. Among authors: van antwerpen p. Eur J Med Chem. 2016 Nov 10;123:746-762. doi: 10.1016/j.ejmech.2016.07.053. Epub 2016 Jul 25. Eur J Med Chem. 2016. PMID: 27537923
From Dynamic Combinatorial Chemistry to in Vivo Evaluation of Reversible and Irreversible Myeloperoxidase Inhibitors.
Soubhye J, Gelbcke M, Van Antwerpen P, Dufrasne F, Boufadi MY, Nève J, Furtmüller PG, Obinger C, Zouaoui Boudjeltia K, Meyer F. Soubhye J, et al. Among authors: van antwerpen p. ACS Med Chem Lett. 2016 Dec 2;8(2):206-210. doi: 10.1021/acsmedchemlett.6b00417. eCollection 2017 Feb 9. ACS Med Chem Lett. 2016. PMID: 28197313 Free PMC article.
122 results