Bourne PE - Search Results

1

Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62.

Tsai LC, Xie L, Dore K, Xie L, Del Rio JC, King CC, Martinez-Ariza G, Hulme C, Malinow R, Bourne PE, Newton AC. Tsai LC, et al. Among authors: bourne pe. J Biol Chem. 2015 Sep 4;290(36):21845-56. doi: 10.1074/jbc.M115.676221. Epub 2015 Jul 17. J Biol Chem. 2015. PMID: 26187466 Free PMC article.

2

A robust and efficient algorithm for the shape description of protein structures and its application in predicting ligand binding sites.

Xie L, Bourne PE. Xie L, et al. Among authors: bourne pe. BMC Bioinformatics. 2007 May 22;8 Suppl 4(Suppl 4):S9. doi: 10.1186/1471-2105-8-S4-S9. BMC Bioinformatics. 2007. PMID: 17570152 Free PMC article.

3

Delineation of Polypharmacology across the Human Structural Kinome Using a Functional Site Interaction Fingerprint Approach.

Zhao Z, Xie L, Xie L, Bourne PE. Zhao Z, et al. Among authors: bourne pe. J Med Chem. 2016 May 12;59(9):4326-41. doi: 10.1021/acs.jmedchem.5b02041. Epub 2016 Mar 17. J Med Chem. 2016. PMID: 26929980 Free PMC article.

4

Determining Cysteines Available for Covalent Inhibition Across the Human Kinome.

Zhao Z, Liu Q, Bliven S, Xie L, Bourne PE. Zhao Z, et al. Among authors: bourne pe. J Med Chem. 2017 Apr 13;60(7):2879-2889. doi: 10.1021/acs.jmedchem.6b01815. Epub 2017 Apr 4. J Med Chem. 2017. PMID: 28326775 Free PMC article.

5

Insights into the binding mode of MEK type-III inhibitors. A step towards discovering and designing allosteric kinase inhibitors across the human kinome.

Zhao Z, Xie L, Bourne PE. Zhao Z, et al. Among authors: bourne pe. PLoS One. 2017 Jun 19;12(6):e0179936. doi: 10.1371/journal.pone.0179936. eCollection 2017. PLoS One. 2017. PMID: 28628649 Free PMC article.

6

Functional coverage of the human genome by existing structures, structural genomics targets, and homology models.

Xie L, Bourne PE. Xie L, et al. Among authors: bourne pe. PLoS Comput Biol. 2005 Aug;1(3):e31. doi: 10.1371/journal.pcbi.0010031. Epub 2005 Aug 19. PLoS Comput Biol. 2005. PMID: 16118666 Free PMC article.

7

In silico elucidation of the molecular mechanism defining the adverse effect of selective estrogen receptor modulators.

Xie L, Wang J, Bourne PE. Xie L, et al. Among authors: bourne pe. PLoS Comput Biol. 2007 Nov;3(11):e217. doi: 10.1371/journal.pcbi.0030217. Epub 2007 Sep 26. PLoS Comput Biol. 2007. PMID: 18052534 Free PMC article.

8

Detecting evolutionary relationships across existing fold space, using sequence order-independent profile-profile alignments.

Xie L, Bourne PE. Xie L, et al. Among authors: bourne pe. Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5441-6. doi: 10.1073/pnas.0704422105. Epub 2008 Apr 2. Proc Natl Acad Sci U S A. 2008. PMID: 18385384 Free PMC article.

9

A unified statistical model to support local sequence order independent similarity searching for ligand-binding sites and its application to genome-based drug discovery.

Xie L, Xie L, Bourne PE. Xie L, et al. Among authors: bourne pe. Bioinformatics. 2009 Jun 15;25(12):i305-12. doi: 10.1093/bioinformatics/btp220. Bioinformatics. 2009. PMID: 19478004 Free PMC article.

10

Drug discovery using chemical systems biology: weak inhibition of multiple kinases may contribute to the anti-cancer effect of nelfinavir.

Xie L, Evangelidis T, Xie L, Bourne PE. Xie L, et al. Among authors: bourne pe. PLoS Comput Biol. 2011 Apr;7(4):e1002037. doi: 10.1371/journal.pcbi.1002037. Epub 2011 Apr 28. PLoS Comput Biol. 2011. PMID: 21552547 Free PMC article.

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