Humphries LA - Search Results

1

Discs Large Homolog 1 Splice Variants Regulate p38-Dependent and -Independent Effector Functions in CD8+ T Cells.

Silva O, Crocetti J, Humphries LA, Burkhardt JK, Miceli MC. Silva O, et al. Among authors: humphries la. PLoS One. 2015 Jul 17;10(7):e0133353. doi: 10.1371/journal.pone.0133353. eCollection 2015. PLoS One. 2015. PMID: 26186728 Free PMC article.

2

Characterization of in vivo Dlg1 deletion on T cell development and function.

Humphries LA, Shaffer MH, Sacirbegovic F, Tomassian T, McMahon KA, Humbert PO, Silva O, Round JL, Takamiya K, Huganir RL, Burkhardt JK, Russell SM, Miceli MC. Humphries LA, et al. PLoS One. 2012;7(9):e45276. doi: 10.1371/journal.pone.0045276. Epub 2012 Sep 18. PLoS One. 2012. PMID: 23028902 Free PMC article.

3

Selective phosphorylation of the Dlg1AB variant is critical for TCR-induced p38 activation and induction of proinflammatory cytokines in CD8+ T cells.

Crocetti J, Silva O, Humphries LA, Tibbs MD, Miceli MC. Crocetti J, et al. Among authors: humphries la. J Immunol. 2014 Sep 15;193(6):2651-60. doi: 10.4049/jimmunol.1401196. Epub 2014 Aug 6. J Immunol. 2014. PMID: 25098293 Free PMC article.

4

Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-kappaB transcription factors.

Round JL, Humphries LA, Tomassian T, Mittelstadt P, Zhang M, Miceli MC. Round JL, et al. Among authors: humphries la. Nat Immunol. 2007 Feb;8(2):154-61. doi: 10.1038/ni1422. Epub 2006 Dec 24. Nat Immunol. 2007. PMID: 17187070

5

Caveolin-1 orchestrates TCR synaptic polarity, signal specificity, and function in CD8 T cells.

Tomassian T, Humphries LA, Liu SD, Silva O, Brooks DG, Miceli MC. Tomassian T, et al. Among authors: humphries la. J Immunol. 2011 Sep 15;187(6):2993-3002. doi: 10.4049/jimmunol.1101447. Epub 2011 Aug 17. J Immunol. 2011. PMID: 21849673 Free PMC article.

6

Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker.

Humphries LA, Dangelmaier C, Sommer K, Kipp K, Kato RM, Griffith N, Bakman I, Turk CW, Daniel JL, Rawlings DJ. Humphries LA, et al. J Biol Chem. 2004 Sep 3;279(36):37651-61. doi: 10.1074/jbc.M311985200. Epub 2004 Jun 7. J Biol Chem. 2004. PMID: 15184383 Free article.

7

PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling.

Su TT, Guo B, Kawakami Y, Sommer K, Chae K, Humphries LA, Kato RM, Kang S, Patrone L, Wall R, Teitell M, Leitges M, Kawakami T, Rawlings DJ. Su TT, et al. Among authors: humphries la. Nat Immunol. 2002 Aug;3(8):780-6. doi: 10.1038/ni823. Epub 2002 Jul 15. Nat Immunol. 2002. PMID: 12118249

8

CD38 signaling regulates B lymphocyte activation via a phospholipase C (PLC)-gamma 2-independent, protein kinase C, phosphatidylcholine-PLC, and phospholipase D-dependent signaling cascade.

Moreno-García ME, López-Bojórques LN, Zentella A, Humphries LA, Rawlings DJ, Santos-Argumedo L. Moreno-García ME, et al. Among authors: humphries la. J Immunol. 2005 Mar 1;174(5):2687-95. doi: 10.4049/jimmunol.174.5.2687. J Immunol. 2005. PMID: 15728476

9

Calcium signalling and cell-fate choice in B cells.

Scharenberg AM, Humphries LA, Rawlings DJ. Scharenberg AM, et al. Among authors: humphries la. Nat Rev Immunol. 2007 Oct;7(10):778-89. doi: 10.1038/nri2172. Nat Rev Immunol. 2007. PMID: 17853903 Free PMC article. Review.

10

A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation.

Clayton E, Bardi G, Bell SE, Chantry D, Downes CP, Gray A, Humphries LA, Rawlings D, Reynolds H, Vigorito E, Turner M. Clayton E, et al. Among authors: humphries la. J Exp Med. 2002 Sep 16;196(6):753-63. doi: 10.1084/jem.20020805. J Exp Med. 2002. PMID: 12235209 Free PMC article.

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