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Page 1
Atu027, a liposomal small interfering RNA formulation targeting protein kinase N3, inhibits cancer progression.
Aleku M, Schulz P, Keil O, Santel A, Schaeper U, Dieckhoff B, Janke O, Endruschat J, Durieux B, Röder N, Löffler K, Lange C, Fechtner M, Möpert K, Fisch G, Dames S, Arnold W, Jochims K, Giese K, Wiedenmann B, Scholz A, Kaufmann J. Aleku M, et al. Among authors: dames s. Cancer Res. 2008 Dec 1;68(23):9788-98. doi: 10.1158/0008-5472.CAN-08-2428. Cancer Res. 2008. PMID: 19047158
Atu027 prevents pulmonary metastasis in experimental and spontaneous mouse metastasis models.
Santel A, Aleku M, Röder N, Möpert K, Durieux B, Janke O, Keil O, Endruschat J, Dames S, Lange C, Eisermann M, Löffler K, Fechtner M, Fisch G, Vank C, Schaeper U, Giese K, Kaufmann J. Santel A, et al. Among authors: dames s. Clin Cancer Res. 2010 Nov 15;16(22):5469-80. doi: 10.1158/1078-0432.CCR-10-1994. Epub 2010 Nov 9. Clin Cancer Res. 2010. PMID: 21062934
PKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase.
Leenders F, Möpert K, Schmiedeknecht A, Santel A, Czauderna F, Aleku M, Penschuck S, Dames S, Sternberger M, Röhl T, Wellmann A, Arnold W, Giese K, Kaufmann J, Klippel A. Leenders F, et al. Among authors: dames s. EMBO J. 2004 Aug 18;23(16):3303-13. doi: 10.1038/sj.emboj.7600345. Epub 2004 Jul 29. EMBO J. 2004. PMID: 15282551 Free PMC article.
SLN124, a GalNac-siRNA targeting transmembrane serine protease 6, in combination with deferiprone therapy reduces ineffective erythropoiesis and hepatic iron-overload in a mouse model of β-thalassaemia.
Vadolas J, Ng GZ, Kysenius K, Crouch PJ, Dames S, Eisermann M, Nualkaew T, Vilcassim S, Schaeper U, Grigoriadis G. Vadolas J, et al. Among authors: dames s. Br J Haematol. 2021 Jul;194(1):200-210. doi: 10.1111/bjh.17428. Epub 2021 May 4. Br J Haematol. 2021. PMID: 33942901 Free PMC article.
Magnesium accumulation upon cyclin M4 silencing activates microsomal triglyceride transfer protein improving NASH.
Simón J, Goikoetxea-Usandizaga N, Serrano-Maciá M, Fernández-Ramos D, Sáenz de Urturi D, Gruskos JJ, Fernández-Tussy P, Lachiondo-Ortega S, González-Recio I, Rodríguez-Agudo R, Gutiérrez-de-Juan V, Rodríguez-Iruretagoyena B, Varela-Rey M, Gimenez-Mascarell P, Mercado-Gomez M, Gómez-Santos B, Fernandez-Rodriguez C, Lopitz-Otsoa F, Bizkarguenaga M, Dames S, Schaeper U, Martin F, Sabio G, Iruzubieta P, Crespo J, Aspichueta P, Chu KH, Buccella D, Martín C, Delgado TC, Martínez-Cruz LA, Martínez-Chantar ML. Simón J, et al. Among authors: dames s. J Hepatol. 2021 Jul;75(1):34-45. doi: 10.1016/j.jhep.2021.01.043. Epub 2021 Feb 9. J Hepatol. 2021. PMID: 33571553 Free PMC article.
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