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Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism.
Haslbeck V, Drazic A, Eckl JM, Alte F, Helmuth M, Popowicz G, Schmidt W, Braun F, Weiwad M, Fischer G, Gemmecker G, Sattler M, Striggow F, Groll M, Richter K. Haslbeck V, et al. Among authors: popowicz g. Biosci Rep. 2015 Apr 20;35(3):e00210. doi: 10.1042/BSR20150042. Biosci Rep. 2015. PMID: 26182372 Free PMC article.
Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites.
Dawidowski M, Emmanouilidis L, Kalel VC, Tripsianes K, Schorpp K, Hadian K, Kaiser M, Mäser P, Kolonko M, Tanghe S, Rodriguez A, Schliebs W, Erdmann R, Sattler M, Popowicz GM. Dawidowski M, et al. Among authors: popowicz gm. Science. 2017 Mar 31;355(6332):1416-1420. doi: 10.1126/science.aal1807. Science. 2017. PMID: 28360328
Identification of small-molecule inhibitors of USP2a.
Tomala MD, Magiera-Mularz K, Kubica K, Krzanik S, Zieba B, Musielak B, Pustula M, Popowicz GM, Sattler M, Dubin G, Skalniak L, Holak TA. Tomala MD, et al. Among authors: popowicz gm. Eur J Med Chem. 2018 Apr 25;150:261-267. doi: 10.1016/j.ejmech.2018.03.009. Epub 2018 Mar 5. Eur J Med Chem. 2018. PMID: 29529503
Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity.
Brenke JK, Popowicz GM, Schorpp K, Rothenaigner I, Roesner M, Meininger I, Kalinski C, Ringelstetter L, R'kyek O, Jürjens G, Vincendeau M, Plettenburg O, Sattler M, Krappmann D, Hadian K. Brenke JK, et al. Among authors: popowicz gm. J Biol Chem. 2018 Aug 24;293(34):13191-13203. doi: 10.1074/jbc.RA118.002649. Epub 2018 Jun 27. J Biol Chem. 2018. PMID: 29950522 Free PMC article.
110 results