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Page 1
Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern.
Pfeffer I, Brewitz L, Krojer T, Jensen SA, Kochan GT, Kershaw NJ, Hewitson KS, McNeill LA, Kramer H, Münzel M, Hopkinson RJ, Oppermann U, Handford PA, McDonough MA, Schofield CJ. Pfeffer I, et al. Among authors: hewitson ks. Nat Commun. 2019 Oct 28;10(1):4910. doi: 10.1038/s41467-019-12711-7. Nat Commun. 2019. PMID: 31659163 Free PMC article.
Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion.
Tervonen TA, Belitškin D, Pant SM, Englund JI, Marques E, Ala-Hongisto H, Nevalaita L, Sihto H, Heikkilä P, Leidenius M, Hewitson K, Ramachandra M, Moilanen A, Joensuu H, Kovanen PE, Poso A, Klefström J. Tervonen TA, et al. Among authors: hewitson k. Oncogene. 2016 Apr 7;35(14):1832-46. doi: 10.1038/onc.2015.248. Epub 2015 Jul 13. Oncogene. 2016. PMID: 26165838
Direct analysis of enzyme-catalyzed DNA demethylation.
Karkhanina AA, Mecinović J, Musheev MU, Krylova SM, Petrov AP, Hewitson KS, Flashman E, Schofield CJ, Krylov SN. Karkhanina AA, et al. Among authors: hewitson ks. Anal Chem. 2009 Jul 15;81(14):5871-5. doi: 10.1021/ac9010556. Anal Chem. 2009. PMID: 19518090
Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.
Flashman E, Bagg EA, Chowdhury R, Mecinović J, Loenarz C, McDonough MA, Hewitson KS, Schofield CJ. Flashman E, et al. Among authors: hewitson ks. J Biol Chem. 2008 Feb 15;283(7):3808-15. doi: 10.1074/jbc.M707411200. Epub 2007 Dec 5. J Biol Chem. 2008. PMID: 18063574 Free article.
48 results