Botas J - Search Results

1

Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation.

El-Daher MT, Hangen E, Bruyère J, Poizat G, Al-Ramahi I, Pardo R, Bourg N, Souquere S, Mayet C, Pierron G, Lévêque-Fort S, Botas J, Humbert S, Saudou F. El-Daher MT, et al. Among authors: botas j. EMBO J. 2015 Sep 2;34(17):2255-71. doi: 10.15252/embj.201490808. Epub 2015 Jul 12. EMBO J. 2015. PMID: 26165689 Free PMC article.

2

The level of DLDB/CHIP controls the activity of the LIM homeodomain protein apterous: evidence for a functional tetramer complex in vivo.

Rincón-Limas DE, Lu CH, Canal I, Botas J. Rincón-Limas DE, et al. Among authors: botas j. EMBO J. 2000 Jun 1;19(11):2602-14. doi: 10.1093/emboj/19.11.2602. EMBO J. 2000. PMID: 10835358 Free PMC article.

3

MBNL1 and CUGBP1 modify expanded CUG-induced toxicity in a Drosophila model of myotonic dystrophy type 1.

de Haro M, Al-Ramahi I, De Gouyon B, Ukani L, Rosa A, Faustino NA, Ashizawa T, Cooper TA, Botas J. de Haro M, et al. Among authors: botas j. Hum Mol Genet. 2006 Jul 1;15(13):2138-45. doi: 10.1093/hmg/ddl137. Epub 2006 May 24. Hum Mol Genet. 2006. PMID: 16723374

4

CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation.

Al-Ramahi I, Lam YC, Chen HK, de Gouyon B, Zhang M, Pérez AM, Branco J, de Haro M, Patterson C, Zoghbi HY, Botas J. Al-Ramahi I, et al. Among authors: botas j. J Biol Chem. 2006 Sep 8;281(36):26714-24. doi: 10.1074/jbc.M601603200. Epub 2006 Jul 10. J Biol Chem. 2006. PMID: 16831871 Free article.

5

Comparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases.

Branco J, Al-Ramahi I, Ukani L, Pérez AM, Fernandez-Funez P, Rincón-Limas D, Botas J. Branco J, et al. Among authors: botas j. Hum Mol Genet. 2008 Feb 1;17(3):376-90. doi: 10.1093/hmg/ddm315. Epub 2007 Nov 5. Hum Mol Genet. 2008. PMID: 17984172

6

dAtaxin-2 mediates expanded Ataxin-1-induced neurodegeneration in a Drosophila model of SCA1.

Al-Ramahi I, Pérez AM, Lim J, Zhang M, Sorensen R, de Haro M, Branco J, Pulst SM, Zoghbi HY, Botas J. Al-Ramahi I, et al. Among authors: botas j. PLoS Genet. 2007 Dec 28;3(12):e234. doi: 10.1371/journal.pgen.0030234. Epub 2007 Nov 16. PLoS Genet. 2007. PMID: 18166084 Free PMC article.

7

Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm.

Romero E, Cha GH, Verstreken P, Ly CV, Hughes RE, Bellen HJ, Botas J. Romero E, et al. Among authors: botas j. Neuron. 2008 Jan 10;57(1):27-40. doi: 10.1016/j.neuron.2007.11.025. Neuron. 2008. PMID: 18184562 Free PMC article.

8

Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease.

Miller JP, Holcomb J, Al-Ramahi I, de Haro M, Gafni J, Zhang N, Kim E, Sanhueza M, Torcassi C, Kwak S, Botas J, Hughes RE, Ellerby LM. Miller JP, et al. Among authors: botas j. Neuron. 2010 Jul 29;67(2):199-212. doi: 10.1016/j.neuron.2010.06.021. Neuron. 2010. PMID: 20670829 Free PMC article.

9

Inhibition of lipid signaling enzyme diacylglycerol kinase epsilon attenuates mutant huntingtin toxicity.

Zhang N, Li B, Al-Ramahi I, Cong X, Held JM, Kim E, Botas J, Gibson BW, Ellerby LM. Zhang N, et al. Among authors: botas j. J Biol Chem. 2012 Jun 15;287(25):21204-13. doi: 10.1074/jbc.M111.321661. Epub 2012 Apr 16. J Biol Chem. 2012. PMID: 22511757 Free PMC article.

10

Network organization of the huntingtin proteomic interactome in mammalian brain.

Shirasaki DI, Greiner ER, Al-Ramahi I, Gray M, Boontheung P, Geschwind DH, Botas J, Coppola G, Horvath S, Loo JA, Yang XW. Shirasaki DI, et al. Among authors: botas j. Neuron. 2012 Jul 12;75(1):41-57. doi: 10.1016/j.neuron.2012.05.024. Neuron. 2012. PMID: 22794259 Free PMC article.

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