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Page 1
Discovery of a BTK/MNK dual inhibitor for lymphoma and leukemia.
Wu H, Hu C, Wang A, Weisberg EL, Chen Y, Yun CH, Wang W, Liu Y, Liu X, Tian B, Wang J, Zhao Z, Liang Y, Li B, Wang L, Wang B, Chen C, Buhrlage SJ, Qi Z, Zou F, Nonami A, Li Y, Fernandes SM, Adamia S, Stone RM, Galinsky IA, Wang X, Yang G, Griffin JD, Brown JR, Eck MJ, Liu J, Gray NS, Liu Q. Wu H, et al. Among authors: qi z. Leukemia. 2016 Jan;30(1):173-81. doi: 10.1038/leu.2015.180. Epub 2015 Jul 13. Leukemia. 2016. PMID: 26165234 Free PMC article.
Neuronal Cdc2-like kinases: neuron-specific forms of Cdk5.
Lee KY, QI Z, Yu YP, Wang JH. Lee KY, et al. Among authors: qi z. Int J Biochem Cell Biol. 1997 Jul;29(7):951-8. doi: 10.1016/s1357-2725(97)00048-4. Int J Biochem Cell Biol. 1997. PMID: 9375376 Review.
Cloning of three novel neuronal Cdk5 activator binding proteins.
Ching YP, Qi Z, Wang JH. Ching YP, et al. Among authors: qi z. Gene. 2000 Jan 25;242(1-2):285-94. doi: 10.1016/s0378-1119(99)00499-0. Gene. 2000. PMID: 10721722
The active kinase consists of a catalytic subunit, Cdk5, and a 25 kDa activator protein (p25nck5a) derived from a 35 kDa neuronal-specific protein (p35nck5a). As an extension of our previous study (Qi, Z., Tang, D., Zhu, X., Fujita, D.J., Wang, J.H., 1998. Associati …
The active kinase consists of a catalytic subunit, Cdk5, and a 25 kDa activator protein (p25nck5a) derived from a 35 kDa neuronal-specific p …
Identification of a common protein association region in the neuronal Cdk5 activator.
Wang X, Ching YP, Lam WH, Qi Z, Zhang M, Wang JH. Wang X, et al. Among authors: qi z. J Biol Chem. 2000 Oct 13;275(41):31763-9. doi: 10.1074/jbc.M004358200. J Biol Chem. 2000. PMID: 10915792 Free article.
A variety of cellular proteins have been shown to undergo high affinity association with Nck5a, including three novel proteins, C42, C48, and C53 found by a yeast two-hybrid screen (Ching, Y. P., Qi, Z., and Wang, J. H. (2000) Gene 242, 285-294). The three proteins …
A variety of cellular proteins have been shown to undergo high affinity association with Nck5a, including three novel proteins, C42, C48, an …
Discovery of (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2-(dimethylamino)ethanone (CHMFL-FLT3-122) as a Potent and Orally Available FLT3 Kinase Inhibitor for FLT3-ITD Positive Acute Myeloid Leukemia.
Li X, Wang A, Yu K, Qi Z, Chen C, Wang W, Hu C, Wu H, Wu J, Zhao Z, Liu J, Zou F, Wang L, Wang B, Wang W, Zhang S, Liu J, Liu Q. Li X, et al. Among authors: qi z. J Med Chem. 2015 Dec 24;58(24):9625-38. doi: 10.1021/acs.jmedchem.5b01611. Epub 2015 Dec 14. J Med Chem. 2015. PMID: 26630553
Discovery of 2-((3-Amino-4-methylphenyl)amino)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-ABL-053) as a Potent, Selective, and Orally Available BCR-ABL/SRC/p38 Kinase Inhibitor for Chronic Myeloid Leukemia.
Liang X, Liu X, Wang B, Zou F, Wang A, Qi S, Chen C, Zhao Z, Wang W, Qi Z, Lv F, Hu Z, Wang L, Zhang S, Liu Q, Liu J. Liang X, et al. Among authors: qi z, qi s. J Med Chem. 2016 Mar 10;59(5):1984-2004. doi: 10.1021/acs.jmedchem.5b01618. Epub 2016 Feb 5. J Med Chem. 2016. PMID: 26789553
Discovery of N-(3-((1-Isonicotinoylpiperidin-4-yl)oxy)-4-methylphenyl)-3-(trifluoromethyl)benzamide (CHMFL-KIT-110) as a Selective, Potent, and Orally Available Type II c-KIT Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs).
Wang Q, Liu F, Wang B, Zou F, Chen C, Liu X, Wang A, Qi S, Wang W, Qi Z, Zhao Z, Hu Z, Wang W, Wang L, Zhang S, Wang Y, Liu J, Liu Q. Wang Q, et al. Among authors: qi z, qi s. J Med Chem. 2016 Apr 28;59(8):3964-79. doi: 10.1021/acs.jmedchem.6b00200. Epub 2016 Apr 14. J Med Chem. 2016. PMID: 27077705
Discovery of a highly potent FLT3 kinase inhibitor for FLT3-ITD-positive AML.
Wu H, Wang A, Qi Z, Li X, Chen C, Yu K, Zou F, Hu C, Wang W, Zhao Z, Wu J, Liu J, Liu X, Wang L, Wang W, Zhang S, Stone RM, Galinsky IA, Griffin JD, Weinstock D, Christodoulou A, Wang H, Shen Y, Zhai Z, Weisberg EL, Liu J, Liu Q. Wu H, et al. Among authors: qi z. Leukemia. 2016 Oct;30(10):2112-2116. doi: 10.1038/leu.2016.151. Epub 2016 May 25. Leukemia. 2016. PMID: 27220667 Free PMC article. No abstract available.
4,584 results