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IMMUNODEFICIENCIES. Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations.
Okada S, Markle JG, Deenick EK, Mele F, Averbuch D, Lagos M, Alzahrani M, Al-Muhsen S, Halwani R, Ma CS, Wong N, Soudais C, Henderson LA, Marzouqa H, Shamma J, Gonzalez M, Martinez-Barricarte R, Okada C, Avery DT, Latorre D, Deswarte C, Jabot-Hanin F, Torrado E, Fountain J, Belkadi A, Itan Y, Boisson B, Migaud M, Arlehamn CSL, Sette A, Breton S, McCluskey J, Rossjohn J, de Villartay JP, Moshous D, Hambleton S, Latour S, Arkwright PD, Picard C, Lantz O, Engelhard D, Kobayashi M, Abel L, Cooper AM, Notarangelo LD, Boisson-Dupuis S, Puel A, Sallusto F, Bustamante J, Tangye SG, Casanova JL. Okada S, et al. Among authors: lantz o. Science. 2015 Aug 7;349(6248):606-613. doi: 10.1126/science.aaa4282. Epub 2015 Jul 9. Science. 2015. PMID: 26160376 Free PMC article.
Stepwise development of MAIT cells in mouse and human.
Martin E, Treiner E, Duban L, Guerri L, Laude H, Toly C, Premel V, Devys A, Moura IC, Tilloy F, Cherif S, Vera G, Latour S, Soudais C, Lantz O. Martin E, et al. Among authors: lantz o. PLoS Biol. 2009 Mar 10;7(3):e54. doi: 10.1371/journal.pbio.1000054. PLoS Biol. 2009. PMID: 19278296 Free PMC article.
MAIT cells detect and efficiently lyse bacterially-infected epithelial cells.
Le Bourhis L, Dusseaux M, Bohineust A, Bessoles S, Martin E, Premel V, Coré M, Sleurs D, Serriari NE, Treiner E, Hivroz C, Sansonetti P, Gougeon ML, Soudais C, Lantz O. Le Bourhis L, et al. Among authors: lantz o. PLoS Pathog. 2013;9(10):e1003681. doi: 10.1371/journal.ppat.1003681. Epub 2013 Oct 10. PLoS Pathog. 2013. PMID: 24130485 Free PMC article.
Mucosal-associated invariant T cell-rich congenic mouse strain allows functional evaluation.
Cui Y, Franciszkiewicz K, Mburu YK, Mondot S, Le Bourhis L, Premel V, Martin E, Kachaner A, Duban L, Ingersoll MA, Rabot S, Jaubert J, De Villartay JP, Soudais C, Lantz O. Cui Y, et al. Among authors: lantz o. J Clin Invest. 2015 Nov 2;125(11):4171-85. doi: 10.1172/JCI82424. Epub 2015 Oct 12. J Clin Invest. 2015. PMID: 26524590 Free PMC article.
MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immunopathology and immunosuppression.
Shaler CR, Choi J, Rudak PT, Memarnejadian A, Szabo PA, Tun-Abraham ME, Rossjohn J, Corbett AJ, McCluskey J, McCormick JK, Lantz O, Hernandez-Alejandro R, Haeryfar SMM. Shaler CR, et al. Among authors: lantz o. PLoS Biol. 2017 Jun 20;15(6):e2001930. doi: 10.1371/journal.pbio.2001930. eCollection 2017 Jun. PLoS Biol. 2017. PMID: 28632753 Free PMC article.
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