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Dominant transmission of insulin resistance in a type A family resulting from a heterozygous nonsense mutation in the insulin receptor gene and associated with decreased mRNA level and insulin binding sites.
Magré J, Karayanni C, Hadjiathanasiou CG, Desbois-Mouthon C, Meier M, Vigouroux C, Stavrinadis C, Sinaniotis C, Caron M, Capeau J. Magré J, et al. Diabetes. 1997 Nov;46(11):1901-3. doi: 10.2337/diab.46.11.1901. Diabetes. 1997. PMID: 9356044 No abstract available.
Antiinsulin receptor autoantibodies induce insulin receptors to constitutively associate with insulin receptor substrate-1 and -2 and cause severe cell resistance to both insulin and insulin-like growth factor I.
Auclair M, Vigouroux C, Desbois-Mouthon C, Deibener J, Kaminski P, Lascols O, Cherqui G, Capeau J, Caron M. Auclair M, et al. J Clin Endocrinol Metab. 1999 Sep;84(9):3197-206. doi: 10.1210/jcem.84.9.5965. J Clin Endocrinol Metab. 1999. PMID: 10487687
Insulin-like growth factor-1 receptor inhibition induces a resistance mechanism via the epidermal growth factor receptor/HER3/AKT signaling pathway: rational basis for cotargeting insulin-like growth factor-1 receptor and epidermal growth factor receptor in hepatocellular carcinoma.
Desbois-Mouthon C, Baron A, Blivet-Van Eggelpoël MJ, Fartoux L, Venot C, Bladt F, Housset C, Rosmorduc O. Desbois-Mouthon C, et al. Clin Cancer Res. 2009 Sep 1;15(17):5445-56. doi: 10.1158/1078-0432.CCR-08-2980. Epub 2009 Aug 25. Clin Cancer Res. 2009. PMID: 19706799
52 results