Hartley JA - Search Results

1

AzaHx, a novel fluorescent, DNA minor groove and G·C recognition element: Synthesis and DNA binding properties of a p-anisyl-4-aza-benzimidazole-pyrrole-imidazole (azaHx-PI) polyamide.

Satam V, Babu B, Patil P, Brien KA, Olson K, Savagian M, Lee M, Mepham A, Jobe LB, Bingham JP, Pett L, Wang S, Ferrara M, Bruce CD, Wilson WD, Lee M, Hartley JA, Kiakos K. Satam V, et al. Among authors: hartley ja. Bioorg Med Chem Lett. 2015 Sep 1;25(17):3681-5. doi: 10.1016/j.bmcl.2015.06.055. Epub 2015 Jun 19. Bioorg Med Chem Lett. 2015. PMID: 26122210

2

DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards is preserved in intact cells.

Hartley JA, Bingham JP, Souhami RL. Hartley JA, et al. Nucleic Acids Res. 1992 Jun 25;20(12):3175-8. doi: 10.1093/nar/20.12.3175. Nucleic Acids Res. 1992. PMID: 1620613 Free PMC article.

3

Interaction of bisantrene anti-cancer agents with DNA: footprinting, structural requirements for DNA unwinding, kinetics and mechanism of binding and correlation of structural and kinetic parameters with anti-cancer activity.

Elliott JA, Wilson WD, Shea RG, Hartley JA, Reszka K, Lown JW. Elliott JA, et al. Among authors: hartley ja. Anticancer Drug Des. 1989 Mar;3(4):271-82. Anticancer Drug Des. 1989. PMID: 2539168

4

Sequence specificity of alkylation for a series of nitrogen mustard-containing analogues of distamycin of increasing binding site size: evidence for increased cytotoxicity with enhanced sequence specificity.

Wyatt MD, Lee M, Garbiras BJ, Souhami RL, Hartley JA. Wyatt MD, et al. Among authors: hartley ja. Biochemistry. 1995 Oct 10;34(40):13034-41. doi: 10.1021/bi00040a014. Biochemistry. 1995. PMID: 7548062

5

Novel cytotoxic DNA sequence and minor groove targeted photosensitizers: conjugates of pyrene and netropsin analogues.

Hartley JA, Webber J, Wyatt MD, Bordenick N, Lee M. Hartley JA, et al. Bioorg Med Chem. 1995 Jun;3(6):623-9. doi: 10.1016/0968-0896(95)00050-q. Bioorg Med Chem. 1995. PMID: 7582941

6

The effect of AT and GC sequence specific minor groove-binding agents on restriction endonuclease activity.

Forrow SM, Lee M, Souhami RL, Hartley JA. Forrow SM, et al. Among authors: hartley ja. Chem Biol Interact. 1995 May 19;96(2):125-42. doi: 10.1016/0009-2797(94)03577-u. Chem Biol Interact. 1995. PMID: 7728903

7

DNA damage by anticancer agents and its repair: mapping in cells at the subgene level with quantitative polymerase chain reaction.

Grimaldi KA, Bingham JP, Souhami RL, Hartley JA. Grimaldi KA, et al. Among authors: hartley ja. Anal Biochem. 1994 Oct;222(1):236-42. doi: 10.1006/abio.1994.1479. Anal Biochem. 1994. PMID: 7856855

8

Structure-activity relationship of a series of nitrogen mustard- and pyrrole-containing minor groove-binding agents related to distamycin.

Wyatt MD, Garbiras BJ, Haskell MK, Lee M, Souhami RL, Hartley JA. Wyatt MD, et al. Among authors: hartley ja. Anticancer Drug Des. 1994 Dec;9(6):511-25. Anticancer Drug Des. 1994. PMID: 7880376

9

GC sequence specific recognition by an N-formamido, C-terminus-modified and imidazole-containing analogue of netropsin.

Lee M, Preti CS, Vinson E, Wyatt MD, Hartley JA. Lee M, et al. Among authors: hartley ja. J Med Chem. 1994 Nov 25;37(24):4073-5. doi: 10.1021/jm00050a003. J Med Chem. 1994. PMID: 7990106 No abstract available.

10

Molecular and cellular pharmacology of novel photoactive psoralen and coumarin conjugates of pyrrole- and imidazole-containing analogues of netropsin.

Hartley JA, McAdam SR, Das S, Roldan MC, Haskell MK, Lee M. Hartley JA, et al. Anticancer Drug Des. 1994 Jun;9(3):181-97. Anticancer Drug Des. 1994. PMID: 8031451

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