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Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells.
Hendel A, Bak RO, Clark JT, Kennedy AB, Ryan DE, Roy S, Steinfeld I, Lunstad BD, Kaiser RJ, Wilkens AB, Bacchetta R, Tsalenko A, Dellinger D, Bruhn L, Porteus MH. Hendel A, et al. Among authors: porteus mh. Nat Biotechnol. 2015 Sep;33(9):985-989. doi: 10.1038/nbt.3290. Epub 2015 Jun 29. Nat Biotechnol. 2015. PMID: 26121415 Free PMC article.
Gene editing: not just for translation anymore.
McMahon MA, Rahdar M, Porteus M. McMahon MA, et al. Nat Methods. 2011 Dec 28;9(1):28-31. doi: 10.1038/nmeth.1811. Nat Methods. 2011. PMID: 22205513 No abstract available.
Quantifying on- and off-target genome editing.
Hendel A, Fine EJ, Bao G, Porteus MH. Hendel A, et al. Among authors: porteus mh. Trends Biotechnol. 2015 Feb;33(2):132-40. doi: 10.1016/j.tibtech.2014.12.001. Epub 2015 Jan 13. Trends Biotechnol. 2015. PMID: 25595557 Free PMC article. Review.
Genome Editing: A New Approach to Human Therapeutics.
Porteus M. Porteus M. Annu Rev Pharmacol Toxicol. 2016;56:163-90. doi: 10.1146/annurev-pharmtox-010814-124454. Epub 2015 Nov 9. Annu Rev Pharmacol Toxicol. 2016. PMID: 26566154 Review.
Knock-in editing: it functionally corrects!
Porteus MH. Porteus MH. Blood. 2016 May 26;127(21):2507-9. doi: 10.1182/blood-2016-03-703181. Blood. 2016. PMID: 27231391 Free PMC article.
189 results