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Metronidazole-triazole conjugates: activity against Clostridium difficile and parasites.
Jarrad AM, Karoli T, Debnath A, Tay CY, Huang JX, Kaeslin G, Elliott AG, Miyamoto Y, Ramu S, Kavanagh AM, Zuegg J, Eckmann L, Blaskovich MA, Cooper MA. Jarrad AM, et al. Among authors: eckmann l. Eur J Med Chem. 2015 Aug 28;101:96-102. doi: 10.1016/j.ejmech.2015.06.019. Epub 2015 Jun 18. Eur J Med Chem. 2015. PMID: 26117821 Free PMC article.
Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia.
Valdez CA, Tripp JC, Miyamoto Y, Kalisiak J, Hruz P, Andersen YS, Brown SE, Kangas K, Arzu LV, Davids BJ, Gillin FD, Upcroft JA, Upcroft P, Fokin VV, Smith DK, Sharpless KB, Eckmann L. Valdez CA, et al. Among authors: eckmann l. J Med Chem. 2009 Jul 9;52(13):4038-53. doi: 10.1021/jm900356n. J Med Chem. 2009. PMID: 19480409 Free PMC article.
Expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity.
Miyamoto Y, Kalisiak J, Korthals K, Lauwaet T, Cheung DY, Lozano R, Cobo ER, Upcroft P, Upcroft JA, Berg DE, Gillin FD, Fokin VV, Sharpless KB, Eckmann L. Miyamoto Y, et al. Among authors: eckmann l. Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17564-9. doi: 10.1073/pnas.1302664110. Epub 2013 Oct 7. Proc Natl Acad Sci U S A. 2013. PMID: 24101497 Free PMC article.
Hsp90 inhibitors as new leads to target parasitic diarrheal diseases.
Debnath A, Shahinas D, Bryant C, Hirata K, Miyamoto Y, Hwang G, Gut J, Renslo AR, Pillai DR, Eckmann L, Reed SL, McKerrow JH. Debnath A, et al. Among authors: eckmann l. Antimicrob Agents Chemother. 2014 Jul;58(7):4138-44. doi: 10.1128/AAC.02576-14. Epub 2014 May 12. Antimicrob Agents Chemother. 2014. PMID: 24820073 Free PMC article.
Microbiota Protects Mice Against Acute Alcohol-Induced Liver Injury.
Chen P, Miyamoto Y, Mazagova M, Lee KC, Eckmann L, Schnabl B. Chen P, et al. Among authors: eckmann l. Alcohol Clin Exp Res. 2015 Dec;39(12):2313-23. doi: 10.1111/acer.12900. Epub 2015 Nov 11. Alcohol Clin Exp Res. 2015. PMID: 26556636 Free PMC article.
311 results