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Discovery of Novel and Orally Bioavailable Inhibitors of PI3 Kinase Based on Indazole Substituted Morpholino-Triazines.
Dugar S, Hollinger FP, Mahajan D, Sen S, Kuila B, Arora R, Pawar Y, Shinde V, Rahinj M, Kapoor KK, Bhumkar R, Rai S, Kulkarni R. Dugar S, et al. Among authors: hollinger fp. ACS Med Chem Lett. 2015 Nov 2;6(12):1190-4. doi: 10.1021/acsmedchemlett.5b00322. eCollection 2015 Dec 10. ACS Med Chem Lett. 2015. PMID: 26713102 Free PMC article.
Two classes of p38alpha MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes.
Michelotti EL, Moffett KK, Nguyen D, Kelly MJ, Shetty R, Chai X, Northrop K, Namboodiri V, Campbell B, Flynn GA, Fujimoto T, Hollinger FP, Bukhtiyarova M, Springman EB, Karpusas M. Michelotti EL, et al. Among authors: hollinger fp. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5274-9. doi: 10.1016/j.bmcl.2005.08.038. Epub 2005 Sep 19. Bioorg Med Chem Lett. 2005. PMID: 16169718
Exploring the role of bromine at C(10) of (+)-4-[2-[4-(8-chloro-3,10-dibromo- 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(R)-yl)-1-piperidinyl]-2- oxoethyl]-1-piperidinecarboxamide (Sch-66336): the discovery of indolocycloheptapyridine inhibitors of farnesyl protein transferase.
Taveras AG, Aki C, Chao J, Doll RJ, Lalwani T, Girijavallabhan V, Strickland CL, Windsor WT, Weber P, Hollinger F, Snow M, Patton R, Kirschmeier P, James L, Liu M, Nomeir A. Taveras AG, et al. J Med Chem. 2002 Aug 29;45(18):3854-64. doi: 10.1021/jm010463v. J Med Chem. 2002. PMID: 12190309