Zhang LS - Search Results

1

Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure-Activity Relationship Study.

Xu LL, Zhu JF, Xu XL, Zhu J, Li L, Xi MY, Jiang ZY, Zhang MY, Liu F, Lu MC, Bao QC, Li Q, Zhang C, Wei JL, Zhang XJ, Zhang LS, You QD, Sun HP. Xu LL, et al. Among authors: zhang ls, zhang c, zhang my, zhang xj. J Med Chem. 2015 Jul 23;58(14):5419-36. doi: 10.1021/acs.jmedchem.5b00170. Epub 2015 Jul 7. J Med Chem. 2015. PMID: 26111355

2

Palladium(II)-Catalyzed C-H Bond Activation/C-C Coupling/Intramolecular Tsuji-Trost Reaction Cascade: Facile Access to 2H-Pyranonaphthoquinones.

Bian J, Qian X, Wang N, Mu T, Li X, Sun H, Zhang L, You Q, Zhang X. Bian J, et al. Org Lett. 2015 Jul 17;17(14):3410-3. doi: 10.1021/acs.orglett.5b01304. Epub 2015 Jul 7. Org Lett. 2015. PMID: 26151353

3

Affinity-Based Fluorescence Polarization Assay for High-Throughput Screening of Prolyl Hydroxylase 2 Inhibitors.

Lei Y, Hu T, Wu X, Wu Y, Bao Q, Zhang L, Xia H, Sun H, You Q, Zhang X. Lei Y, et al. ACS Med Chem Lett. 2015 Nov 9;6(12):1236-40. doi: 10.1021/acsmedchemlett.5b00394. eCollection 2015 Dec 10. ACS Med Chem Lett. 2015. PMID: 26713111 Free PMC article.

4

Discovery of EBI-907: A highly potent and orally active B-Raf(V600E) inhibitor for the treatment of melanoma and associated cancers.

Lu B, Cao H, Cao J, Huang S, Hu Q, Liu D, Shen R, Shen X, Tao W, Wan H, Wang D, Yan Y, Yang L, Zhang J, Zhang L, Zhang L, Zhang M. Lu B, et al. Bioorg Med Chem Lett. 2016 Feb 1;26(3):819-823. doi: 10.1016/j.bmcl.2015.12.086. Epub 2015 Dec 24. Bioorg Med Chem Lett. 2016. PMID: 26739779

5

Discovery of EBI-1051: A novel and orally efficacious MEK inhibitor with benzofuran scaffold.

Lu B, Huang S, Cao J, Hu Q, Shen R, Wan H, Wang D, Yuan J, Zhang L, Zhang J, Zhang M, Tao W, Zhang L. Lu B, et al. Bioorg Med Chem. 2018 Feb 1;26(3):581-589. doi: 10.1016/j.bmc.2017.12.019. Epub 2017 Dec 20. Bioorg Med Chem. 2018. PMID: 29317148

6

Discovery of Imidazoisoindole Derivatives as Highly Potent and Orally Active Indoleamine-2,3-dioxygenase Inhibitors.

Tu W, Yang F, Xu G, Chi J, Liu Z, Peng W, Hu B, Zhang L, Wan H, Yu N, Jin F, Hu Q, Zhang L, He F, Tao W. Tu W, et al. ACS Med Chem Lett. 2019 Jun 3;10(6):949-953. doi: 10.1021/acsmedchemlett.9b00114. eCollection 2019 Jun 13. ACS Med Chem Lett. 2019. PMID: 31223453 Free PMC article.

7

Discovery of Clinical Candidate (5-(3-(4-Chlorophenoxy)prop-1-yn-1-yl)-3-hydroxypicolinoyl)glycine, an Orally Bioavailable Prolyl Hydroxylase Inhibitor for the Treatment of Anemia.

Zhang X, Lei Y, Hu T, Wu Y, Li Z, Jiang Z, Yang C, Zhang L, You Q. Zhang X, et al. J Med Chem. 2020 Sep 10;63(17):10045-10060. doi: 10.1021/acs.jmedchem.0c01161. Epub 2020 Aug 5. J Med Chem. 2020. PMID: 32787144

8

Design, synthesis and bioevaluation of inhibitors targeting HSP90-CDC37 protein-protein interaction based on a hydrophobic core.

Zhang Q, Wu X, Zhou J, Zhang L, Xu X, Zhang L, You Q, Wang L. Zhang Q, et al. Eur J Med Chem. 2021 Jan 15;210:112959. doi: 10.1016/j.ejmech.2020.112959. Epub 2020 Oct 22. Eur J Med Chem. 2021. PMID: 33109397

9

Discovery of Hydroxyamidine Derivatives as Highly Potent, Selective Indoleamine-2,3-dioxygenase 1 Inhibitors.

Jin F, Hu Q, Fei H, Lv H, Wang S, Gui B, Zhang J, Tu W, Zhang Y, Zhang L, Wan H, Zhang L, Hu B, Yang F, Bai C, He F, Zhang L, Tao W. Jin F, et al. ACS Med Chem Lett. 2021 Jan 20;12(2):195-201. doi: 10.1021/acsmedchemlett.0c00443. eCollection 2021 Feb 11. ACS Med Chem Lett. 2021. PMID: 33603965 Free PMC article.

10

Strategies for Targeting Serine/Threonine Protein Phosphatases with Small Molecules in Cancer.

Zhang Q, Fan Z, Zhang L, You Q, Wang L. Zhang Q, et al. J Med Chem. 2021 Jul 8;64(13):8916-8938. doi: 10.1021/acs.jmedchem.1c00631. Epub 2021 Jun 22. J Med Chem. 2021. PMID: 34156850 Review.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

616 results

Search Page

Filters