Xu LL - Search Results

1

Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure-Activity Relationship Study.

Xu LL, Zhu JF, Xu XL, Zhu J, Li L, Xi MY, Jiang ZY, Zhang MY, Liu F, Lu MC, Bao QC, Li Q, Zhang C, Wei JL, Zhang XJ, Zhang LS, You QD, Sun HP. Xu LL, et al. Among authors: xu xl. J Med Chem. 2015 Jul 23;58(14):5419-36. doi: 10.1021/acs.jmedchem.5b00170. Epub 2015 Jul 7. J Med Chem. 2015. PMID: 26111355

2

Identification, design and bio-evaluation of novel Hsp90 inhibitors by ligand-based virtual screening.

Jia J, Xu X, Liu F, Guo X, Zhang M, Lu M, Xu L, Wei J, Zhu J, Zhang S, Zhang S, Sun H, You Q. Jia J, et al. PLoS One. 2013;8(4):e59315. doi: 10.1371/journal.pone.0059315. Epub 2013 Apr 2. PLoS One. 2013. PMID: 23565147 Free PMC article.

3

Effective screening strategy using ensembled pharmacophore models combined with cascade docking: application to p53-MDM2 interaction inhibitors.

Xue X, Wei JL, Xu LL, Xi MY, Xu XL, Liu F, Guo XK, Wang L, Zhang XJ, Zhang MY, Lu MC, Sun HP, You QD. Xue X, et al. Among authors: xu ll, xu xl. J Chem Inf Model. 2013 Oct 28;53(10):2715-29. doi: 10.1021/ci400348f. Epub 2013 Oct 7. J Chem Inf Model. 2013. PMID: 24050442

4

3-aroylmethylene-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-ones as potent Nrf2/ARE inducers in human cancer cells and AOM-DSS treated mice.

Xi MY, Jia JM, Sun HP, Sun ZY, Jiang JW, Wang YJ, Zhang MY, Zhu JF, Xu LL, Jiang ZY, Xue X, Ye M, Yang X, Gao Y, Tao L, Guo XK, Xu XL, Guo QL, Zhang XJ, Hu R, You QD. Xi MY, et al. Among authors: xu ll, xu xl. J Med Chem. 2013 Oct 24;56(20):7925-38. doi: 10.1021/jm400944k. Epub 2013 Oct 9. J Med Chem. 2013. PMID: 24053646

5

Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis.

Jiang ZY, Lu MC, Xu LL, Yang TT, Xi MY, Xu XL, Guo XK, Zhang XJ, You QD, Sun HP. Jiang ZY, et al. Among authors: xu ll, xu xl. J Med Chem. 2014 Mar 27;57(6):2736-45. doi: 10.1021/jm5000529. Epub 2014 Feb 21. J Med Chem. 2014. PMID: 24512214

6

2-Substituted 3-methylnaphtho[1,2-b]furan-4,5-diones as novel L-shaped ortho-quinone substrates for NAD(P)H:quinone oxidoreductase (NQO1).

Bian J, Deng B, Xu L, Xu X, Wang N, Hu T, Yao Z, Du J, Yang L, Lei Y, Li X, Sun H, Zhang X, You Q. Bian J, et al. Eur J Med Chem. 2014 Jul 23;82:56-67. doi: 10.1016/j.ejmech.2014.05.041. Epub 2014 May 14. Eur J Med Chem. 2014. PMID: 24874653

7

Investigation of the intermolecular recognition mechanism between the E3 ubiquitin ligase Keap1 and substrate based on multiple substrates analysis.

Jiang ZY, Xu LL, Lu MC, Pan Y, Huang HZ, Zhang XJ, Sun HP, You QD. Jiang ZY, et al. Among authors: xu ll. J Comput Aided Mol Des. 2014 Dec;28(12):1233-45. doi: 10.1007/s10822-014-9799-y. Epub 2014 Oct 10. J Comput Aided Mol Des. 2014. PMID: 25301376

8

Synthesis and evaluation of (±)-dunnione and its ortho-quinone analogues as substrates for NAD(P)H:quinone oxidoreductase 1 (NQO1).

Bian J, Xu L, Deng B, Qian X, Fan J, Yang X, Liu F, Xu X, Guo X, Li X, Sun H, You Q, Zhang X. Bian J, et al. Bioorg Med Chem Lett. 2015 Mar 15;25(6):1244-8. doi: 10.1016/j.bmcl.2015.01.057. Epub 2015 Jan 31. Bioorg Med Chem Lett. 2015. PMID: 25677663

9

Discovery of novel potent and selective ligands for 5-HT2A receptor with quinazoline scaffold.

Deng X, Guo L, Xu L, Zhen X, Yu K, Zhao W, Fu W. Deng X, et al. Bioorg Med Chem Lett. 2015 Sep 15;25(18):3970-4. doi: 10.1016/j.bmcl.2015.07.030. Epub 2015 Jul 18. Bioorg Med Chem Lett. 2015. PMID: 26227779

10

Structure-Activity and Structure-Property Relationship and Exploratory in Vivo Evaluation of the Nanomolar Keap1-Nrf2 Protein-Protein Interaction Inhibitor.

Jiang ZY, Xu LL, Lu MC, Chen ZY, Yuan ZW, Xu XL, Guo XK, Zhang XJ, Sun HP, You QD. Jiang ZY, et al. Among authors: xu ll, xu xl. J Med Chem. 2015 Aug 27;58(16):6410-21. doi: 10.1021/acs.jmedchem.5b00185. Epub 2015 Aug 14. J Med Chem. 2015. PMID: 26258437

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