Liu F - Search Results

1

Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure-Activity Relationship Study.

Xu LL, Zhu JF, Xu XL, Zhu J, Li L, Xi MY, Jiang ZY, Zhang MY, Liu F, Lu MC, Bao QC, Li Q, Zhang C, Wei JL, Zhang XJ, Zhang LS, You QD, Sun HP. Xu LL, et al. Among authors: liu f. J Med Chem. 2015 Jul 23;58(14):5419-36. doi: 10.1021/acs.jmedchem.5b00170. Epub 2015 Jul 7. J Med Chem. 2015. PMID: 26111355

2

Synthesis and evaluation of a novel class Hsp90 inhibitors containing 1-phenylpiperazine scaffold.

Jia JM, Liu F, Xu XL, Guo XK, Jiang F, Cherfaoui B, Sun HP, You QD. Jia JM, et al. Among authors: liu f. Bioorg Med Chem Lett. 2014 Mar 15;24(6):1557-61. doi: 10.1016/j.bmcl.2014.01.070. Epub 2014 Feb 15. Bioorg Med Chem Lett. 2014. PMID: 24582477

3

Identification and optimization of novel Hsp90 inhibitors with tetrahydropyrido[4,3-d]pyrimidines core through shape-based screening.

Sun HP, Jia JM, Jiang F, Xu XL, Liu F, Guo XK, Cherfaoui B, Huang HZ, Pan Y, You QD. Sun HP, et al. Among authors: liu f. Eur J Med Chem. 2014 May 22;79:399-412. doi: 10.1016/j.ejmech.2014.03.061. Epub 2014 Mar 21. Eur J Med Chem. 2014. PMID: 24763261

4

Novel 5-carboxy-8-HQ based histone demethylase JMJD2A inhibitors: introduction of an additional carboxyl group at the C-2 position of quinoline.

Feng T, Li D, Wang H, Zhuang J, Liu F, Bao Q, Lei Y, Chen W, Zhang X, Xu X, Sun H, You Q, Guo X. Feng T, et al. Among authors: liu f. Eur J Med Chem. 2015 Nov 13;105:145-55. doi: 10.1016/j.ejmech.2015.09.013. Epub 2015 Sep 10. Eur J Med Chem. 2015. PMID: 26491978

5

Novel Tetrahydropyrido[4,3-d]pyrimidines as Potent Inhibitors of Chaperone Heat Shock Protein 90.

Jiang F, Wang HJ, Jin YH, Zhang Q, Wang ZH, Jia JM, Liu F, Wang L, Bao QC, Li DD, You QD, Xu XL. Jiang F, et al. Among authors: liu f. J Med Chem. 2016 Dec 8;59(23):10498-10519. doi: 10.1021/acs.jmedchem.6b00912. Epub 2016 Nov 22. J Med Chem. 2016. PMID: 27933959

6

Synthesis and evaluation of (±)-dunnione and its ortho-quinone analogues as substrates for NAD(P)H:quinone oxidoreductase 1 (NQO1).

Bian J, Xu L, Deng B, Qian X, Fan J, Yang X, Liu F, Xu X, Guo X, Li X, Sun H, You Q, Zhang X. Bian J, et al. Among authors: liu f. Bioorg Med Chem Lett. 2015 Mar 15;25(6):1244-8. doi: 10.1016/j.bmcl.2015.01.057. Epub 2015 Jan 31. Bioorg Med Chem Lett. 2015. PMID: 25677663

7

Escape, or Vanish: Control the Fate of p53 through MDM2-Mediated Ubiquitination.

Wei J, Yang Y, Lu M, Xu L, Liu F, Yuan Z, Bao Q, Jiang Z, Xu X, Guo X, Zhang X, You Q, Sun H. Wei J, et al. Among authors: liu f. Anticancer Agents Med Chem. 2015;16(2):174-89. doi: 10.2174/1871520615666150907093358. Anticancer Agents Med Chem. 2015. PMID: 26343143 Review.

8

CPUY201112, a novel synthetic small-molecule compound and inhibitor of heat shock protein Hsp90, induces p53-mediated apoptosis in MCF-7 cells.

Xu XL, Bao QC, Jia JM, Liu F, Guo XK, Zhang MY, Wei JL, Lu MC, Xu LL, Zhang XJ, You QD, Sun HP. Xu XL, et al. Among authors: liu f. Sci Rep. 2016 Jan 8;6:19004. doi: 10.1038/srep19004. Sci Rep. 2016. PMID: 26743233 Free PMC article.

9

Synthesis and evaluation of 4-(2-hydroxypropyl)piperazin-1-yl) derivatives as Hsp90 inhibitors.

Cherfaoui B, Guo TK, Sun HP, Cheng WL, Liu F, Jiang F, Xu XL, You QD. Cherfaoui B, et al. Among authors: liu f. Bioorg Med Chem. 2016 Jun 1;24(11):2423-2432. doi: 10.1016/j.bmc.2016.03.049. Epub 2016 Apr 7. Bioorg Med Chem. 2016. PMID: 27134115

10

Discovery and Bioevaluation of Novel Pyrazolopyrimidine Analogs as Competitive Hsp90 Inhibitors Through Shape-Based Similarity Screening.

Xu XL, Sun HP, Liu F, Jia JM, Guo XK, Pan Y, Huang HZ, Zhang XJ, You QD. Xu XL, et al. Among authors: liu f. Mol Inform. 2014 Apr;33(4):293-306. doi: 10.1002/minf.201300150. Epub 2014 Apr 11. Mol Inform. 2014. PMID: 27485776

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