Bao QC - Search Results

1

Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure-Activity Relationship Study.

Xu LL, Zhu JF, Xu XL, Zhu J, Li L, Xi MY, Jiang ZY, Zhang MY, Liu F, Lu MC, Bao QC, Li Q, Zhang C, Wei JL, Zhang XJ, Zhang LS, You QD, Sun HP. Xu LL, et al. Among authors: bao qc. J Med Chem. 2015 Jul 23;58(14):5419-36. doi: 10.1021/acs.jmedchem.5b00170. Epub 2015 Jul 7. J Med Chem. 2015. PMID: 26111355

2

Escape, or Vanish: Control the Fate of p53 through MDM2-Mediated Ubiquitination.

Wei J, Yang Y, Lu M, Xu L, Liu F, Yuan Z, Bao Q, Jiang Z, Xu X, Guo X, Zhang X, You Q, Sun H. Wei J, et al. Anticancer Agents Med Chem. 2015;16(2):174-89. doi: 10.2174/1871520615666150907093358. Anticancer Agents Med Chem. 2015. PMID: 26343143 Review.

3

Novel 5-carboxy-8-HQ based histone demethylase JMJD2A inhibitors: introduction of an additional carboxyl group at the C-2 position of quinoline.

Feng T, Li D, Wang H, Zhuang J, Liu F, Bao Q, Lei Y, Chen W, Zhang X, Xu X, Sun H, You Q, Guo X. Feng T, et al. Eur J Med Chem. 2015 Nov 13;105:145-55. doi: 10.1016/j.ejmech.2015.09.013. Epub 2015 Sep 10. Eur J Med Chem. 2015. PMID: 26491978

4

Affinity-Based Fluorescence Polarization Assay for High-Throughput Screening of Prolyl Hydroxylase 2 Inhibitors.

Lei Y, Hu T, Wu X, Wu Y, Bao Q, Zhang L, Xia H, Sun H, You Q, Zhang X. Lei Y, et al. ACS Med Chem Lett. 2015 Nov 9;6(12):1236-40. doi: 10.1021/acsmedchemlett.5b00394. eCollection 2015 Dec 10. ACS Med Chem Lett. 2015. PMID: 26713111 Free PMC article.

5

CPUY201112, a novel synthetic small-molecule compound and inhibitor of heat shock protein Hsp90, induces p53-mediated apoptosis in MCF-7 cells.

Xu XL, Bao QC, Jia JM, Liu F, Guo XK, Zhang MY, Wei JL, Lu MC, Xu LL, Zhang XJ, You QD, Sun HP. Xu XL, et al. Among authors: bao qc. Sci Rep. 2016 Jan 8;6:19004. doi: 10.1038/srep19004. Sci Rep. 2016. PMID: 26743233 Free PMC article.

6

Optimization and biological evaluation of celastrol derivatives as Hsp90-Cdc37 interaction disruptors with improved druglike properties.

Jiang F, Wang HJ, Bao QC, Wang L, Jin YH, Zhang Q, Jiang D, You QD, Xu XL. Jiang F, et al. Among authors: bao qc. Bioorg Med Chem. 2016 Nov 1;24(21):5431-5439. doi: 10.1016/j.bmc.2016.08.070. Epub 2016 Sep 1. Bioorg Med Chem. 2016. PMID: 27647369

7

NRF2 promotes breast cancer cell proliferation and metastasis by increasing RhoA/ROCK pathway signal transduction.

Zhang C, Wang HJ, Bao QC, Wang L, Guo TK, Chen WL, Xu LL, Zhou HS, Bian JL, Yang YR, Sun HP, Xu XL, You QD. Zhang C, et al. Among authors: bao qc. Oncotarget. 2016 Nov 8;7(45):73593-73606. doi: 10.18632/oncotarget.12435. Oncotarget. 2016. PMID: 27713154 Free PMC article.

8

Novel Natural Product-like Caged Xanthones Bearing a Carbamate Moiety Exhibit Antitumor Potency and Anti-Angiogenesis Activity In vivo.

Xu X, Wu Y, Hu M, Li X, Bao Q, Bian J, You Q, Zhang X. Xu X, et al. Sci Rep. 2016 Oct 21;6:35771. doi: 10.1038/srep35771. Sci Rep. 2016. PMID: 27767192 Free PMC article.

9

Novel Tetrahydropyrido[4,3-d]pyrimidines as Potent Inhibitors of Chaperone Heat Shock Protein 90.

Jiang F, Wang HJ, Jin YH, Zhang Q, Wang ZH, Jia JM, Liu F, Wang L, Bao QC, Li DD, You QD, Xu XL. Jiang F, et al. Among authors: bao qc. J Med Chem. 2016 Dec 8;59(23):10498-10519. doi: 10.1021/acs.jmedchem.6b00912. Epub 2016 Nov 22. J Med Chem. 2016. PMID: 27933959

10

Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer.

Wang L, Zhang L, Li L, Jiang J, Zheng Z, Shang J, Wang C, Chen W, Bao Q, Xu X, Jiang Z, Zhang J, You Q. Wang L, et al. Sci Adv. 2019 Sep 18;5(9):eaax2277. doi: 10.1126/sciadv.aax2277. eCollection 2019 Sep. Sci Adv. 2019. PMID: 31555737 Free PMC article.

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