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The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease.
Oñate M, Catenaccio A, Salvadores N, Saquel C, Martinez A, Moreno-Gonzalez I, Gamez N, Soto P, Soto C, Hetz C, Court FA. Oñate M, et al. Among authors: martinez a. Cell Death Differ. 2020 Apr;27(4):1169-1185. doi: 10.1038/s41418-019-0408-4. Epub 2019 Oct 7. Cell Death Differ. 2020. PMID: 31591470 Free PMC article.
c-Abl Inhibition Activates TFEB and Promotes Cellular Clearance in a Lysosomal Disorder.
Contreras PS, Tapia PJ, González-Hódar L, Peluso I, Soldati C, Napolitano G, Matarese M, Heras ML, Valls C, Martinez A, Balboa E, Castro J, Leal N, Platt FM, Sobota A, Winter D, Klein AD, Medina DL, Ballabio A, Alvarez AR, Zanlungo S. Contreras PS, et al. Among authors: martinez a. iScience. 2020 Oct 15;23(11):101691. doi: 10.1016/j.isci.2020.101691. eCollection 2020 Nov 20. iScience. 2020. PMID: 33163944 Free PMC article.
c-Abl Phosphorylates MFN2 to Regulate Mitochondrial Morphology in Cells under Endoplasmic Reticulum and Oxidative Stress, Impacting Cell Survival and Neurodegeneration.
Martinez A, Lamaizon CM, Valls C, Llambi F, Leal N, Fitzgerald P, Guy C, Kamiński MM, Inestrosa NC, van Zundert B, Cancino GI, Dulcey AE, Zanlungo S, Marugan JJ, Hetz C, Green DR, Alvarez AR. Martinez A, et al. Antioxidants (Basel). 2023 Nov 16;12(11):2007. doi: 10.3390/antiox12112007. Antioxidants (Basel). 2023. PMID: 38001860 Free PMC article.
Artificial enforcement of the unfolded protein response (UPR) reduces disease features in multiple preclinical models of ALS/FTD.
Valenzuela V, Becerra D, Astorga JI, Fuentealba M, Diaz G, Bargsted L, Chacón C, Martinez A, Gozalvo R, Jackson K, Morales V, Heras ML, Tamburini G, Petrucelli L, Sardi P, Plate L, Hetz C. Valenzuela V, et al. Among authors: martinez a. Mol Ther. 2025 Jan 10:S1525-0016(25)00008-5. doi: 10.1016/j.ymthe.2025.01.004. Online ahead of print. Mol Ther. 2025. PMID: 39799393
A new model to study cell-to-cell transfer of αSynuclein in vivo.
Mercado G, López N, Martínez A, Sardi SP, Hetz C. Mercado G, et al. Among authors: martinez a. Biochem Biophys Res Commun. 2018 Sep 10;503(3):1385-1393. doi: 10.1016/j.bbrc.2018.07.053. Epub 2018 Jul 17. Biochem Biophys Res Commun. 2018. PMID: 30025892
8,533 results