Ruan Z - Search Results

1

Mechanistic Insights into R776H Mediated Activation of Epidermal Growth Factor Receptor Kinase.

Ruan Z, Kannan N. Ruan Z, et al. Biochemistry. 2015 Jul 14;54(27):4216-25. doi: 10.1021/acs.biochem.5b00444. Epub 2015 Jul 6. Biochemistry. 2015. PMID: 26101090 Free PMC article.

2

Computational and Experimental Characterization of Patient Derived Mutations Reveal an Unusual Mode of Regulatory Spine Assembly and Drug Sensitivity in EGFR Kinase.

Ruan Z, Katiyar S, Kannan N. Ruan Z, et al. Biochemistry. 2017 Jan 10;56(1):22-32. doi: 10.1021/acs.biochem.6b00572. Epub 2016 Dec 22. Biochemistry. 2017. PMID: 27936599 Free PMC article.

3

Altered conformational landscape and dimerization dependency underpins the activation of EGFR by αC-β4 loop insertion mutations.

Ruan Z, Kannan N. Ruan Z, et al. Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):E8162-E8171. doi: 10.1073/pnas.1803152115. Epub 2018 Aug 13. Proc Natl Acad Sci U S A. 2018. PMID: 30104348 Free PMC article.

4

Conformationally constrained peptides target the allosteric kinase dimer interface and inhibit EGFR activation.

Fulton MD, Hanold LE, Ruan Z, Patel S, Beedle AM, Kannan N, Kennedy EJ. Fulton MD, et al. Among authors: ruan z. Bioorg Med Chem. 2018 Mar 15;26(6):1167-1173. doi: 10.1016/j.bmc.2017.08.051. Epub 2017 Sep 5. Bioorg Med Chem. 2018. PMID: 28911855 Free PMC article.

5

Co-conserved MAPK features couple D-domain docking groove to distal allosteric sites via the C-terminal flanking tail.

Nguyen T, Ruan Z, Oruganty K, Kannan N. Nguyen T, et al. Among authors: ruan z. PLoS One. 2015 Mar 23;10(3):e0119636. doi: 10.1371/journal.pone.0119636. eCollection 2015. PLoS One. 2015. PMID: 25799139 Free PMC article.

6

Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization.

Mohanty S, Oruganty K, Kwon A, Byrne DP, Ferries S, Ruan Z, Hanold LE, Katiyar S, Kennedy EJ, Eyers PA, Kannan N. Mohanty S, et al. Among authors: ruan z. PLoS Genet. 2016 Feb 29;12(2):e1005885. doi: 10.1371/journal.pgen.1005885. eCollection 2016 Feb. PLoS Genet. 2016. PMID: 26925779 Free PMC article.

7

Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources.

Huang LC, Ross KE, Baffi TR, Drabkin H, Kochut KJ, Ruan Z, D'Eustachio P, McSkimming D, Arighi C, Chen C, Natale DA, Smith C, Gaudet P, Newton AC, Wu C, Kannan N. Huang LC, et al. Among authors: ruan z. Sci Rep. 2018 Apr 25;8(1):6518. doi: 10.1038/s41598-018-24457-1. Sci Rep. 2018. PMID: 29695735 Free PMC article.

8

Coupled regulation by the juxtamembrane and sterile α motif (SAM) linker is a hallmark of ephrin tyrosine kinase evolution.

Kwon A, John M, Ruan Z, Kannan N. Kwon A, et al. Among authors: ruan z. J Biol Chem. 2018 Apr 6;293(14):5102-5116. doi: 10.1074/jbc.RA117.001296. Epub 2018 Feb 12. J Biol Chem. 2018. PMID: 29432127 Free PMC article.

9

Emerging roles of the αC-β4 loop in protein kinase structure, function, evolution, and disease.

Yeung W, Ruan Z, Kannan N. Yeung W, et al. Among authors: ruan z. IUBMB Life. 2020 Jun;72(6):1189-1202. doi: 10.1002/iub.2253. Epub 2020 Feb 26. IUBMB Life. 2020. PMID: 32101380 Free PMC article. Review.

10

Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1.

Jamieson SA, Ruan Z, Burgess AE, Curry JR, McMillan HD, Brewster JL, Dunbier AK, Axtman AD, Kannan N, Mace PD. Jamieson SA, et al. Among authors: ruan z. Sci Signal. 2018 Sep 25;11(549):eaau0597. doi: 10.1126/scisignal.aau0597. Sci Signal. 2018. PMID: 30254053 Free PMC article.

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