Lapham K - Search Results

1

Automated Assay of Telomere Length Measurement and Informatics for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort.

Lapham K, Kvale MN, Lin J, Connell S, Croen LA, Dispensa BP, Fang L, Hesselson S, Hoffmann TJ, Iribarren C, Jorgenson E, Kushi LH, Ludwig D, Matsuguchi T, McGuire WB, Miles S, Quesenberry CP Jr, Rowell S, Sadler M, Sakoda LC, Smethurst D, Somkin CP, Van Den Eeden SK, Walter L, Whitmer RA, Kwok PY, Risch N, Schaefer C, Blackburn EH. Lapham K, et al. Genetics. 2015 Aug;200(4):1061-72. doi: 10.1534/genetics.115.178624. Epub 2015 Jun 19. Genetics. 2015. PMID: 26092717 Free PMC article.

2

Telomere length trajectory and its determinants in persons with coronary artery disease: longitudinal findings from the heart and soul study.

Farzaneh-Far R, Lin J, Epel E, Lapham K, Blackburn E, Whooley MA. Farzaneh-Far R, et al. Among authors: lapham k. PLoS One. 2010 Jan 8;5(1):e8612. doi: 10.1371/journal.pone.0008612. PLoS One. 2010. PMID: 20072607 Free PMC article.

3

UGT2B10 is the Major UDP-Glucuronosyltransferase 2B Isoform Involved in the Metabolism of Lamotrigine and is Implicated in the Drug-Drug Interaction with Valproic Acid.

Tang LWT, Lapham K, Goosen TC. Tang LWT, et al. Among authors: lapham k. AAPS J. 2024 Sep 25;26(6):107. doi: 10.1208/s12248-024-00978-8. AAPS J. 2024. PMID: 39322784

4

Clotrimazole Identified as a Selective UGT2B4 Inhibitor Using Canagliflozin-2'-O-Glucuronide Formation as a Selective UGT2B4 Probe Reaction.

Lapham K, Ferguson N, Niosi M, Goosen TC. Lapham K, et al. Drug Metab Dispos. 2024 Sep 16;52(10):1083-1093. doi: 10.1124/dmd.124.001812. Drug Metab Dispos. 2024. PMID: 39142826

5

Evaluation of Icotinib as a Potent and Selective Inhibitor of Aldehyde Oxidase for Reaction Phenotyping in Human Hepatocytes.

Tang LWT, DaSilva E, Lapham K, Obach RS. Tang LWT, et al. Among authors: lapham k. Drug Metab Dispos. 2024 May 16;52(6):565-573. doi: 10.1124/dmd.124.001693. Drug Metab Dispos. 2024. PMID: 38565303

6

Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4.

Londregan AT, Aitmakhanova K, Bennett J, Byrnes LJ, Canterbury DP, Cheng X, Christott T, Clemens J, Coffey SB, Dias JM, Dowling MS, Farnie G, Fedorov O, Fennell KF, Gamble V, Gileadi C, Giroud C, Harris MR, Hollingshead BD, Huber K, Korczynska M, Lapham K, Loria PM, Narayanan A, Owen DR, Raux B, Sahasrabudhe PV, Ruggeri RB, Sáez LD, Stock IA, Thuma BA, Tsai A, Varghese AE. Londregan AT, et al. Among authors: lapham k. J Med Chem. 2023 Jan 12;66(1):460-472. doi: 10.1021/acs.jmedchem.2c01421. Epub 2022 Dec 23. J Med Chem. 2023. PMID: 36562986

7

In Vitro Characterization of Ertugliflozin Metabolism by UDP-Glucuronosyltransferase and Cytochrome P450 Enzymes.

Lapham K, Callegari E, Cianfrogna J, Lin J, Niosi M, Orozco CC, Sharma R, Goosen TC. Lapham K, et al. Drug Metab Dispos. 2020 Dec;48(12):1350-1363. doi: 10.1124/dmd.120.000171. Epub 2020 Oct 5. Drug Metab Dispos. 2020. PMID: 33020067

8

Evidence-based strategies for the characterisation of human drug and chemical glucuronidation in vitro and UDP-glucuronosyltransferase reaction phenotyping.

Miners JO, Rowland A, Novak JJ, Lapham K, Goosen TC. Miners JO, et al. Among authors: lapham k. Pharmacol Ther. 2021 Feb;218:107689. doi: 10.1016/j.pharmthera.2020.107689. Epub 2020 Sep 25. Pharmacol Ther. 2021. PMID: 32980440 Review.

9

Global Portrait of Protein Targets of Metabolites of the Neurotoxic Compound BIA 10-2474.

Huang Z, Ogasawara D, Seneviratne UI, Cognetta AB 3rd, Am Ende CW, Nason DM, Lapham K, Litchfield J, Johnson DS, Cravatt BF. Huang Z, et al. Among authors: lapham k. ACS Chem Biol. 2019 Feb 15;14(2):192-197. doi: 10.1021/acschembio.8b01097. Epub 2019 Jan 31. ACS Chem Biol. 2019. PMID: 30702848 Free PMC article.

10

6-Chloro-5-[4-(1-Hydroxycyclobutyl)Phenyl]-1H-Indole-3-Carboxylic Acid is a Highly Selective Substrate for Glucuronidation by UGT1A1, Relative to β-Estradiol.

Lapham K, Lin J, Novak J, Orozco C, Niosi M, Di L, Goosen TC, Ryu S, Riccardi K, Eng H, Cameron KO, Kalgutkar AS. Lapham K, et al. Drug Metab Dispos. 2018 Dec;46(12):1836-1846. doi: 10.1124/dmd.118.083709. Epub 2018 Sep 7. Drug Metab Dispos. 2018. PMID: 30194276

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