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Page 1
Synthesis and antileukemic activities of C1-C10-modified parthenolide analogues.
Kempema AM, Widen JC, Hexum JK, Andrews TE, Wang D, Rathe SK, Meece FA, Noble KE, Sachs Z, Largaespada DA, Harki DA. Kempema AM, et al. Among authors: hexum jk. Bioorg Med Chem. 2015 Aug 1;23(15):4737-4745. doi: 10.1016/j.bmc.2015.05.037. Epub 2015 May 30. Bioorg Med Chem. 2015. PMID: 26088334 Free PMC article.
Parthenolide prodrug LC-1 slows growth of intracranial glioma.
Hexum JK, Becker CM, Kempema AM, Ohlfest JR, Largaespada DA, Harki DA. Hexum JK, et al. Bioorg Med Chem Lett. 2015 Jun 15;25(12):2493-5. doi: 10.1016/j.bmcl.2015.04.058. Epub 2015 Apr 25. Bioorg Med Chem Lett. 2015. PMID: 25978958
Bicyclic Cyclohexenones as Inhibitors of NF-κB Signaling.
Hexum JK, Tello-Aburto R, Struntz NB, Harned AM, Harki DA. Hexum JK, et al. ACS Med Chem Lett. 2012 Jun 14;3(6):459-464. doi: 10.1021/ml300034a. Epub 2012 May 11. ACS Med Chem Lett. 2012. PMID: 22866208 Free PMC article.
A redox economical synthesis of bioactive 6,12-guaianolides.
Wen B, Hexum JK, Widen JC, Harki DA, Brummond KM. Wen B, et al. Among authors: hexum jk. Org Lett. 2013 Jun 7;15(11):2644-7. doi: 10.1021/ol400904y. Epub 2013 May 10. Org Lett. 2013. PMID: 23662902 Free PMC article.
Nonviral Gene Delivery with Cationic Glycopolymers.
Van Bruggen C, Hexum JK, Tan Z, Dalal RJ, Reineke TM. Van Bruggen C, et al. Among authors: hexum jk. Acc Chem Res. 2019 May 21;52(5):1347-1358. doi: 10.1021/acs.accounts.8b00665. Epub 2019 Apr 17. Acc Chem Res. 2019. PMID: 30993967
Polymeric Delivery of Therapeutic Nucleic Acids.
Kumar R, Santa Chalarca CF, Bockman MR, Bruggen CV, Grimme CJ, Dalal RJ, Hanson MG, Hexum JK, Reineke TM. Kumar R, et al. Among authors: hexum jk. Chem Rev. 2021 Sep 22;121(18):11527-11652. doi: 10.1021/acs.chemrev.0c00997. Epub 2021 May 3. Chem Rev. 2021. PMID: 33939409