Sannajust F - Search Results

1

Inter-study variability of preclinical in vivo safety studies and translational exposure-QTc relationships--a PKPD meta-analysis.

Gotta V, Cools F, van Ammel K, Gallacher DJ, Visser SA, Sannajust F, Morissette P, Danhof M, van der Graaf PH. Gotta V, et al. Among authors: sannajust f. Br J Pharmacol. 2015 Sep;172(17):4364-79. doi: 10.1111/bph.13218. Epub 2015 Jul 21. Br J Pharmacol. 2015. PMID: 26076100 Free PMC article.

2

Sensitivity of pharmacokinetic-pharmacodynamic analysis for detecting small magnitudes of QTc prolongation in preclinical safety testing.

Gotta V, Cools F, van Ammel K, Gallacher DJ, Visser SA, Sannajust F, Morissette P, Danhof M, van der Graaf PH. Gotta V, et al. Among authors: sannajust f. J Pharmacol Toxicol Methods. 2015 Mar-Apr;72:1-10. doi: 10.1016/j.vascn.2014.12.008. Epub 2014 Dec 31. J Pharmacol Toxicol Methods. 2015. PMID: 25556117

3

Application of a systems pharmacology model for translational prediction of hERG-mediated QTc prolongation.

Gotta V, Yu Z, Cools F, van Ammel K, Gallacher DJ, Visser SA, Sannajust F, Morissette P, Danhof M, van der Graaf PH. Gotta V, et al. Among authors: sannajust f. Pharmacol Res Perspect. 2016 Nov 17;4(6):e00270. doi: 10.1002/prp2.270. eCollection 2016 Dec. Pharmacol Res Perspect. 2016. PMID: 28097003 Free PMC article.

4

Shortening of the electromechanical window in the ketamine/xylazine-anesthetized guinea pig model to assess pro-arrhythmic risk in early drug development.

Morissette P, Regan C, Fitzgerald K, Gerenser P, Travis J, Wang S, Fanelli P, Sannajust F. Morissette P, et al. Among authors: sannajust f. J Pharmacol Toxicol Methods. 2016 Sep-Oct;81:171-82. doi: 10.1016/j.vascn.2016.06.003. Epub 2016 Jul 1. J Pharmacol Toxicol Methods. 2016. PMID: 27377419

5

Drug-induced shortening of the electromechanical window is an effective biomarker for in silico prediction of clinical risk of arrhythmias.

Passini E, Trovato C, Morissette P, Sannajust F, Bueno-Orovio A, Rodriguez B. Passini E, et al. Among authors: sannajust f. Br J Pharmacol. 2019 Oct;176(19):3819-3833. doi: 10.1111/bph.14786. Epub 2019 Sep 4. Br J Pharmacol. 2019. PMID: 31271649 Free PMC article.

6

Assessing Drug-Induced Long QT and Proarrhythmic Risk Using Human Stem-Cell-Derived Cardiomyocytes in a Ca2+ Imaging Assay: Evaluation of 28 CiPA Compounds at Three Test Sites.

Lu HR, Zeng H, Kettenhofen R, Guo L, Kopljar I, van Ammel K, Tekle F, Teisman A, Zhai J, Clouse H, Pierson J, Furniss M, Lagrutta A, Sannajust F, Gallacher DJ. Lu HR, et al. Among authors: sannajust f. Toxicol Sci. 2019 Aug 1;170(2):345-356. doi: 10.1093/toxsci/kfz102. Toxicol Sci. 2019. PMID: 31020317 Free PMC article.

7

Combining an in silico proarrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anesthetized guinea pig assay.

Morissette P, Polak S, Chain A, Zhai J, Imredy JP, Wildey MJ, Travis J, Fitzgerald K, Fanelli P, Passini E, Rodriguez B, Sannajust F, Regan C. Morissette P, et al. Among authors: sannajust f. Toxicol Appl Pharmacol. 2020 Mar 1;390:114883. doi: 10.1016/j.taap.2020.114883. Epub 2020 Jan 23. Toxicol Appl Pharmacol. 2020. PMID: 31981640 Free PMC article.

8

Renal studies in safety pharmacology and toxicology: A survey conducted in the top 15 pharmaceutical companies.

Benjamin A, Gallacher DJ, Greiter-Wilke A, Guillon JM, Kasai C, Ledieu D, Levesque P, Prelle K, Ratcliffe S, Sannajust F, Valentin JP. Benjamin A, et al. Among authors: sannajust f. J Pharmacol Toxicol Methods. 2015 Sep-Oct;75:101-10. doi: 10.1016/j.vascn.2015.01.004. Epub 2015 Jan 29. J Pharmacol Toxicol Methods. 2015. PMID: 25637943

9

QT interval correction assessment in the anesthetized guinea pig.

Morissette P, Regan HK, Fitzgerald K, Bernasconi S, Gerenser P, Travis J, Fanelli P, Sannajust F, Regan CP. Morissette P, et al. Among authors: sannajust f. J Pharmacol Toxicol Methods. 2015 Sep-Oct;75:52-61. doi: 10.1016/j.vascn.2015.05.007. Epub 2015 May 19. J Pharmacol Toxicol Methods. 2015. PMID: 26001325

10

Assessment of the clinical cardiac drug-drug interaction associated with the combination of hepatitis C virus nucleotide inhibitors and amiodarone in guinea pigs and rhesus monkeys.

Regan CP, Morissette P, Regan HK, Travis JJ, Gerenser P, Wen J, Fitzgerald K, Gruver S, DeGeorge JJ, Sannajust FJ. Regan CP, et al. Hepatology. 2016 Nov;64(5):1430-1441. doi: 10.1002/hep.28752. Epub 2016 Aug 23. Hepatology. 2016. PMID: 27474787

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