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912 results

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Tristetraprolin impairs myc-induced lymphoma and abolishes the malignant state.
Rounbehler RJ, Fallahi M, Yang C, Steeves MA, Li W, Doherty JR, Schaub FX, Sanduja S, Dixon DA, Blackshear PJ, Cleveland JL. Rounbehler RJ, et al. Among authors: cleveland jl. Cell. 2012 Aug 3;150(3):563-74. doi: 10.1016/j.cell.2012.06.033. Cell. 2012. PMID: 22863009 Free PMC article.
Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties.
Bibian M, Rahaim RJ, Choi JY, Noguchi Y, Schürer S, Chen W, Nakanishi S, Licht K, Rosenberg LH, Li L, Feng Y, Cameron MD, Duckett DR, Cleveland JL, Roush WR. Bibian M, et al. Among authors: cleveland jl. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4374-80. doi: 10.1016/j.bmcl.2013.05.075. Epub 2013 May 31. Bioorg Med Chem Lett. 2013. PMID: 23787102 Free PMC article.
Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis.
Doherty JR, Yang C, Scott KE, Cameron MD, Fallahi M, Li W, Hall MA, Amelio AL, Mishra JK, Li F, Tortosa M, Genau HM, Rounbehler RJ, Lu Y, Dang CV, Kumar KG, Butler AA, Bannister TD, Hooper AT, Unsal-Kacmaz K, Roush WR, Cleveland JL. Doherty JR, et al. Among authors: cleveland jl. Cancer Res. 2014 Feb 1;74(3):908-20. doi: 10.1158/0008-5472.CAN-13-2034. Epub 2013 Nov 27. Cancer Res. 2014. PMID: 24285728 Free PMC article.
Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues.
Seo JW, Ma M, Kwong T, Ju J, Lim SK, Jiang H, Lohman JR, Yang C, Cleveland J, Zazopoulos E, Farnet CM, Shen B. Seo JW, et al. Among authors: cleveland j. Biochemistry. 2014 Dec 16;53(49):7854-65. doi: 10.1021/bi501396v. Epub 2014 Dec 1. Biochemistry. 2014. PMID: 25405956 Free PMC article.
Therapeutic targeting of casein kinase 1δ in breast cancer.
Rosenberg LH, Lafitte M, Quereda V, Grant W, Chen W, Bibian M, Noguchi Y, Fallahi M, Yang C, Chang JC, Roush WR, Cleveland JL, Duckett DR. Rosenberg LH, et al. Sci Transl Med. 2015 Dec 16;7(318):318ra202. doi: 10.1126/scitranslmed.aac8773. Sci Transl Med. 2015. PMID: 26676609 Free PMC article.
Synthesis and Cytoxicity of Sempervirine and Analogues.
Pan X, Yang C, Cleveland JL, Bannister TD. Pan X, et al. J Org Chem. 2016 Mar 4;81(5):2194-200. doi: 10.1021/acs.joc.6b00022. Epub 2016 Feb 10. J Org Chem. 2016. PMID: 26828413 Free PMC article.
912 results