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Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP.
Mukherjee R, Mareninova OA, Odinokova IV, Huang W, Murphy J, Chvanov M, Javed MA, Wen L, Booth DM, Cane MC, Awais M, Gavillet B, Pruss RM, Schaller S, Molkentin JD, Tepikin AV, Petersen OH, Pandol SJ, Gukovsky I, Criddle DN, Gukovskaya AS, Sutton R; NIHR Pancreas Biomedical Research Unit. Mukherjee R, et al. Among authors: javed ma. Gut. 2016 Aug;65(8):1333-46. doi: 10.1136/gutjnl-2014-308553. Epub 2015 Jun 12. Gut. 2016. PMID: 26071131 Free PMC article.
Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca2+-dependent mitochondrial dysfunction and acute pancreatitis.
Huang W, Booth DM, Cane MC, Chvanov M, Javed MA, Elliott VL, Armstrong JA, Dingsdale H, Cash N, Li Y, Greenhalf W, Mukherjee R, Kaphalia BS, Jaffar M, Petersen OH, Tepikin AV, Sutton R, Criddle DN. Huang W, et al. Among authors: javed ma. Gut. 2014 Aug;63(8):1313-24. doi: 10.1136/gutjnl-2012-304058. Epub 2013 Oct 25. Gut. 2014. PMID: 24162590 Free PMC article.
Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models.
Wen L, Voronina S, Javed MA, Awais M, Szatmary P, Latawiec D, Chvanov M, Collier D, Huang W, Barrett J, Begg M, Stauderman K, Roos J, Grigoryev S, Ramos S, Rogers E, Whitten J, Velicelebi G, Dunn M, Tepikin AV, Criddle DN, Sutton R. Wen L, et al. Among authors: javed ma. Gastroenterology. 2015 Aug;149(2):481-92.e7. doi: 10.1053/j.gastro.2015.04.015. Epub 2015 Apr 25. Gastroenterology. 2015. PMID: 25917787 Free PMC article.
198 results