Nano-NRTIs demonstrate low neurotoxicity and high antiviral activity against HIV infection in the brain.
Gerson T, Makarov E, Senanayake TH, Gorantla S, Poluektova LY, Vinogradov SV.
Gerson T, et al. Among authors: makarov e.
Nanomedicine. 2014 Jan;10(1):177-85. doi: 10.1016/j.nano.2013.06.012. Epub 2013 Jul 9.
Nanomedicine. 2014.
PMID: 23845925
Free PMC article.
Previously, we reported that active 5'-triphosphates of NRTIs encapsulated in cationic nanogels (nano-NRTIs) suppress HIV-1 activity more efficiently than NRTIs and exhibit reduced mitochondrial toxicity [Vinogradov SV, Poluektova LY, Makarov E, Gerson T, Senanayake …
Previously, we reported that active 5'-triphosphates of NRTIs encapsulated in cationic nanogels (nano-NRTIs) suppress HIV-1 activity more ef …