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The "OPTI-CLOT" trial. A randomised controlled trial on periOperative PharmacokineTIc-guided dosing of CLOTting factor concentrate in haemophilia A.
Hazendonk HC, van Moort I, Fijnvandraat K, Kruip MJ, Laros-van Gorkom BA, van der Meer FJ, Meijer K, Peters M, Schutgens RE, Zwaan CM, Driessens MH, Polinder S, Leebeek FW, Mathôt RA, Cnossen MH. Hazendonk HC, et al. Among authors: van der meer fj, van moort i. Thromb Haemost. 2015 Aug 31;114(3):639-44. doi: 10.1160/TH14-11-0925. Epub 2015 Jun 11. Thromb Haemost. 2015. PMID: 26062822 Clinical Trial.
Rosuvastatin use increases plasma fibrinolytic potential: a randomised clinical trial.
Schol-Gelok S, de Maat MPM, Biedermann JS, van Gelder T, Leebeek FWG, Lijfering WM, van der Meer FJM, Rijken DC, Versmissen J, Kruip MJHA. Schol-Gelok S, et al. Br J Haematol. 2020 Sep;190(6):916-922. doi: 10.1111/bjh.16648. Epub 2020 Apr 16. Br J Haematol. 2020. PMID: 32301122 Free PMC article. Clinical Trial.
von Willebrand Factor and Factor VIII Clearance in Perioperative Hemophilia A Patients.
van Moort I, Bukkems LH, Heijdra JM, Schutgens REG, Laros-van Gorkom BAP, Nieuwenhuizen L, van der Meer FJM, Fijnvandraat K, Ypma P, de Maat MPM, Leebeek FWG, Meijer K, Eikenboom J, Mathôt RAA, Cnossen MH; OPTI-CLOT Study Group. van Moort I, et al. Thromb Haemost. 2020 Jul;120(7):1056-1065. doi: 10.1055/s-0040-1710591. Epub 2020 Jun 1. Thromb Haemost. 2020. PMID: 32480417 Clinical Trial.
Dosing of factor VIII concentrate by ideal body weight is more accurate in overweight and obese haemophilia A patients.
van Moort I, Preijers T, Hazendonk HCAM, Schutgens REG, Laros-van Gorkom BAP, Nieuwenhuizen L, van der Meer FJM, Fijnvandraat K, Leebeek FWG, Meijer K, Mathôt RAA, Cnossen MH; OPTI-CLOT study group. van Moort I, et al. Br J Clin Pharmacol. 2021 Jun;87(6):2602-2613. doi: 10.1111/bcp.14670. Epub 2020 Dec 16. Br J Clin Pharmacol. 2021. PMID: 33232535 Free PMC article.
Validation of a perioperative population factor VIII pharmacokinetic model with a large cohort of pediatric hemophilia a patients.
Preijers T, Liesner R, Hazendonk HCAM, Chowdary P, Driessens MHE, Hart DP, Laros-van Gorkom BAP, van der Meer FJM, Meijer K, Fijnvandraat K, Leebeek FWG, Mathôt RAA, Cnossen MH; “OPTI-CLOT” study group. Preijers T, et al. Br J Clin Pharmacol. 2021 Nov;87(11):4408-4420. doi: 10.1111/bcp.14864. Epub 2021 May 4. Br J Clin Pharmacol. 2021. PMID: 33884664 Free PMC article.
214 results