Chen W - Search Results

1

High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9.

Varshney GK, Pei W, LaFave MC, Idol J, Xu L, Gallardo V, Carrington B, Bishop K, Jones M, Li M, Harper U, Huang SC, Prakash A, Chen W, Sood R, Ledin J, Burgess SM. Varshney GK, et al. Among authors: chen w. Genome Res. 2015 Jul;25(7):1030-42. doi: 10.1101/gr.186379.114. Epub 2015 Jun 5. Genome Res. 2015. PMID: 26048245 Free PMC article.

2

A large-scale insertional mutagenesis screen in zebrafish.

Amsterdam A, Burgess S, Golling G, Chen W, Sun Z, Townsend K, Farrington S, Haldi M, Hopkins N. Amsterdam A, et al. Among authors: chen w. Genes Dev. 1999 Oct 15;13(20):2713-24. doi: 10.1101/gad.13.20.2713. Genes Dev. 1999. PMID: 10541557 Free PMC article.

3

Analysis of the zebrafish smoothened mutant reveals conserved and divergent functions of hedgehog activity.

Chen W, Burgess S, Hopkins N. Chen W, et al. Development. 2001 Jun;128(12):2385-96. doi: 10.1242/dev.128.12.2385. Development. 2001. PMID: 11493557

4

High-throughput selection of retrovirus producer cell lines leads to markedly improved efficiency of germ line-transmissible insertions in zebra fish.

Chen W, Burgess S, Golling G, Amsterdam A, Hopkins N. Chen W, et al. J Virol. 2002 Mar;76(5):2192-8. doi: 10.1128/jvi.76.5.2192-2198.2002. J Virol. 2002. PMID: 11836396 Free PMC article.

5

The zebrafish spiel-ohne-grenzen (spg) gene encodes the POU domain protein Pou2 related to mammalian Oct4 and is essential for formation of the midbrain and hindbrain, and for pre-gastrula morphogenesis.

Burgess S, Reim G, Chen W, Hopkins N, Brand M. Burgess S, et al. Among authors: chen w. Development. 2002 Feb;129(4):905-16. doi: 10.1242/dev.129.4.905. Development. 2002. PMID: 11861474

6

Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development.

Golling G, Amsterdam A, Sun Z, Antonelli M, Maldonado E, Chen W, Burgess S, Haldi M, Artzt K, Farrington S, Lin SY, Nissen RM, Hopkins N. Golling G, et al. Among authors: chen w. Nat Genet. 2002 Jun;31(2):135-40. doi: 10.1038/ng896. Epub 2002 May 13. Nat Genet. 2002. PMID: 12006978

7

Using retroviruses as a mutagenesis tool to explore the zebrafish genome.

Jao LE, Maddison L, Chen W, Burgess SM. Jao LE, et al. Among authors: chen w. Brief Funct Genomic Proteomic. 2008 Nov;7(6):427-43. doi: 10.1093/bfgp/eln038. Epub 2008 Oct 31. Brief Funct Genomic Proteomic. 2008. PMID: 18977782 Free PMC article. Review.

8

Conditional control of gene function by an invertible gene trap in zebrafish.

Ni TT, Lu J, Zhu M, Maddison LA, Boyd KL, Huskey L, Ju B, Hesselson D, Zhong TP, Page-McCaw PS, Stainier DY, Chen W. Ni TT, et al. Among authors: chen w. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15389-94. doi: 10.1073/pnas.1206131109. Epub 2012 Aug 20. Proc Natl Acad Sci U S A. 2012. PMID: 22908272 Free PMC article.

9

Targeted overexpression of CKI-insensitive cyclin-dependent kinase 4 increases functional β-cell number through enhanced self-replication in zebrafish.

Li M, Maddison LA, Crees Z, Chen W. Li M, et al. Among authors: chen w. Zebrafish. 2013 Jun;10(2):170-6. doi: 10.1089/zeb.2012.0816. Epub 2013 Apr 1. Zebrafish. 2013. PMID: 23544990 Free PMC article.

10

Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system.

Jao LE, Wente SR, Chen W. Jao LE, et al. Among authors: chen w. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13904-9. doi: 10.1073/pnas.1308335110. Epub 2013 Aug 5. Proc Natl Acad Sci U S A. 2013. PMID: 23918387 Free PMC article.

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