Brinton RD - Search Results

1

Allopregnanolone preclinical acute pharmacokinetic and pharmacodynamic studies to predict tolerability and efficacy for Alzheimer's disease.

Irwin RW, Solinsky CM, Loya CM, Salituro FG, Rodgers KE, Bauer G, Rogawski MA, Brinton RD. Irwin RW, et al. Among authors: brinton rd. PLoS One. 2015 Jun 3;10(6):e0128313. doi: 10.1371/journal.pone.0128313. eCollection 2015. PLoS One. 2015. PMID: 26039057 Free PMC article.

2

Preclinical analyses of the therapeutic potential of allopregnanolone to promote neurogenesis in vitro and in vivo in transgenic mouse model of Alzheimer's disease.

Brinton RD, Wang JM. Brinton RD, et al. Curr Alzheimer Res. 2006 Feb;3(1):11-7. doi: 10.2174/156720506775697160. Curr Alzheimer Res. 2006. PMID: 16472197 Review.

3

Therapeutic potential of neurogenesis for prevention and recovery from Alzheimer's disease: allopregnanolone as a proof of concept neurogenic agent.

Brinton RD, Wang JM. Brinton RD, et al. Curr Alzheimer Res. 2006 Jul;3(3):185-90. doi: 10.2174/156720506777632817. Curr Alzheimer Res. 2006. PMID: 16842093 Review.

4

Activation of estrogen receptor alpha increases and estrogen receptor beta decreases apolipoprotein E expression in hippocampus in vitro and in vivo.

Wang JM, Irwin RW, Brinton RD. Wang JM, et al. Among authors: brinton rd. Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16983-8. doi: 10.1073/pnas.0608128103. Epub 2006 Oct 31. Proc Natl Acad Sci U S A. 2006. PMID: 17077142 Free PMC article.

5

Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function.

Nilsen J, Chen S, Irwin RW, Iwamoto S, Brinton RD. Nilsen J, et al. Among authors: brinton rd. BMC Neurosci. 2006 Nov 3;7:74. doi: 10.1186/1471-2202-7-74. BMC Neurosci. 2006. PMID: 17083736 Free PMC article.

6

Regenerative potential of allopregnanolone.

Wang JM, Liu L, Irwin RW, Chen S, Brinton RD. Wang JM, et al. Among authors: brinton rd. Brain Res Rev. 2008 Mar;57(2):398-409. doi: 10.1016/j.brainresrev.2007.08.010. Epub 2007 Sep 14. Brain Res Rev. 2008. PMID: 17931704 Review.

7

Estradiol in vivo regulation of brain mitochondrial proteome.

Nilsen J, Irwin RW, Gallaher TK, Brinton RD. Nilsen J, et al. Among authors: brinton rd. J Neurosci. 2007 Dec 19;27(51):14069-77. doi: 10.1523/JNEUROSCI.4391-07.2007. J Neurosci. 2007. PMID: 18094246 Free PMC article.

8

Regeneration in a degenerating brain: potential of allopregnanolone as a neuroregenerative agent.

Wang JM, Irwin RW, Liu L, Chen S, Brinton RD. Wang JM, et al. Among authors: brinton rd. Curr Alzheimer Res. 2007 Dec;4(5):510-7. doi: 10.2174/156720507783018262. Curr Alzheimer Res. 2007. PMID: 18220513 Free PMC article. Review.

9

Progesterone and estrogen regulate oxidative metabolism in brain mitochondria.

Irwin RW, Yao J, Hamilton RT, Cadenas E, Brinton RD, Nilsen J. Irwin RW, et al. Among authors: brinton rd. Endocrinology. 2008 Jun;149(6):3167-75. doi: 10.1210/en.2007-1227. Epub 2008 Feb 21. Endocrinology. 2008. PMID: 18292191 Free PMC article.

10

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease.

Yao J, Irwin RW, Zhao L, Nilsen J, Hamilton RT, Brinton RD. Yao J, et al. Among authors: brinton rd. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14670-5. doi: 10.1073/pnas.0903563106. Epub 2009 Aug 10. Proc Natl Acad Sci U S A. 2009. PMID: 19667196 Free PMC article.

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