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Page 1
Synthesis and biological evaluation of the natural product komaroviquinone and related compounds aiming at a potential therapeutic lead compound for high-risk multiple myeloma.
Suto Y, Sato M, Fujimori K, Kitabatake S, Okayama M, Ichikawa D, Matsushita M, Yamagiwa N, Iwasaki G, Kiuchi F, Hattori Y. Suto Y, et al. Among authors: iwasaki g. Bioorg Med Chem Lett. 2017 Oct 1;27(19):4558-4563. doi: 10.1016/j.bmcl.2017.08.054. Epub 2017 Aug 30. Bioorg Med Chem Lett. 2017. PMID: 28882484
A novel derivative (GTN024) from a natural product, komaroviquinone, induced the apoptosis of high-risk myeloma cells via reactive oxygen production and ER stress.
Okayama M, Kitabatake S, Sato M, Fujimori K, Ichikawa D, Matsushita M, Suto Y, Iwasaki G, Yamada T, Kiuchi F, Hirao M, Kunieda H, Osada M, Okamoto S, Hattori Y. Okayama M, et al. Among authors: iwasaki g. Biochem Biophys Res Commun. 2018 Nov 2;505(3):787-793. doi: 10.1016/j.bbrc.2018.09.177. Epub 2018 Oct 5. Biochem Biophys Res Commun. 2018. PMID: 30297108
New chemotypes for cathepsin K inhibitors.
Teno N, Irie O, Miyake T, Gohda K, Horiuchi M, Tada S, Nonomura K, Kometani M, Iwasaki G, Betschart C. Teno N, et al. Among authors: iwasaki g. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2599-603. doi: 10.1016/j.bmcl.2008.03.036. Epub 2008 Mar 16. Bioorg Med Chem Lett. 2008. PMID: 18375120
Novel scaffold for cathepsin K inhibitors.
Teno N, Miyake T, Ehara T, Irie O, Sakaki J, Ohmori O, Gunji H, Matsuura N, Masuya K, Hitomi Y, Nonomura K, Horiuchi M, Gohda K, Iwasaki A, Umemura I, Tada S, Kometani M, Iwasaki G, Cowan-Jacob SW, Missbach M, Lattmann R, Betschart C. Teno N, et al. Among authors: iwasaki a, iwasaki g. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6096-100. doi: 10.1016/j.bmcl.2007.09.047. Epub 2007 Sep 15. Bioorg Med Chem Lett. 2007. PMID: 17911019
Discovery of selective and nonpeptidic cathepsin S inhibitors.
Irie O, Ehara T, Iwasaki A, Yokokawa F, Sakaki J, Hirao H, Kanazawa T, Teno N, Horiuchi M, Umemura I, Gunji H, Masuya K, Hitomi Y, Iwasaki G, Nonomura K, Tanabe K, Fukaya H, Kosaka T, Snell CR, Hallett A. Irie O, et al. Among authors: iwasaki g. Bioorg Med Chem Lett. 2008 Jul 15;18(14):3959-62. doi: 10.1016/j.bmcl.2008.06.009. Epub 2008 Jun 10. Bioorg Med Chem Lett. 2008. PMID: 18572405
4-Amino-2-cyanopyrimidines: novel scaffold for nonpeptidic cathepsin S inhibitors.
Irie O, Yokokawa F, Ehara T, Iwasaki A, Iwaki Y, Hitomi Y, Konishi K, Kishida M, Toyao A, Masuya K, Gunji H, Sakaki J, Iwasaki G, Hirao H, Kanazawa T, Tanabe K, Kosaka T, Hart TW, Hallett A. Irie O, et al. Among authors: iwasaki g. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4642-6. doi: 10.1016/j.bmcl.2008.07.011. Epub 2008 Jul 10. Bioorg Med Chem Lett. 2008. PMID: 18662880
Overcoming hERG issues for brain-penetrating cathepsin S inhibitors: 2-cyanopyrimidines. Part 2.
Irie O, Kosaka T, Kishida M, Sakaki J, Masuya K, Konishi K, Yokokawa F, Ehara T, Iwasaki A, Iwaki Y, Hitomi Y, Toyao A, Gunji H, Teno N, Iwasaki G, Hirao H, Kanazawa T, Tanabe K, Hiestand PC, Malcangio M, Fox AJ, Bevan SJ, Yaqoob M, Culshaw AJ, Hart TW, Hallett A. Irie O, et al. Among authors: iwasaki g. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5280-4. doi: 10.1016/j.bmcl.2008.08.067. Epub 2008 Aug 22. Bioorg Med Chem Lett. 2008. PMID: 18783943
Effect of cathepsin K inhibitors on bone resorption.
Teno N, Masuya K, Ehara T, Kosaka T, Miyake T, Irie O, Hitomi Y, Matsuura N, Umemura I, Iwasaki G, Fukaya H, Toriyama K, Uchiyama N, Nonomura K, Sugiyama I, Kometani M. Teno N, et al. Among authors: iwasaki g. J Med Chem. 2008 Sep 11;51(17):5459-62. doi: 10.1021/jm800626a. Epub 2008 Aug 16. J Med Chem. 2008. PMID: 18707091
19 results