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Effects of 5-aza-2'-deoxycytidine on fetal hemoglobin levels, red cell adhesion, and hematopoietic differentiation in patients with sickle cell disease.
Saunthararajah Y, Hillery CA, Lavelle D, Molokie R, Dorn L, Bressler L, Gavazova S, Chen YH, Hoffman R, DeSimone J. Saunthararajah Y, et al. Among authors: lavelle d. Blood. 2003 Dec 1;102(12):3865-70. doi: 10.1182/blood-2003-05-1738. Epub 2003 Aug 7. Blood. 2003. PMID: 12907443 Free article. Clinical Trial.
Efficacy and safety of long-term RN-1 treatment to increase HbF in baboons.
Ibanez V, Vaitkus K, Rivers A, Molokie R, Cui S, Engel JD, DeSimone J, Lavelle D. Ibanez V, et al. Among authors: lavelle d. Blood. 2017 Jan 12;129(2):260-263. doi: 10.1182/blood-2016-10-746727. Epub 2016 Dec 1. Blood. 2017. PMID: 27908882 Free PMC article. No abstract available.
Pharmacological inhibition of LSD1 and mTOR reduces mitochondrial retention and associated ROS levels in the red blood cells of sickle cell disease.
Jagadeeswaran R, Vazquez BA, Thiruppathi M, Ganesh BB, Ibanez V, Cui S, Engel JD, Diamond AM, Molokie RE, DeSimone J, Lavelle D, Rivers A. Jagadeeswaran R, et al. Among authors: lavelle d. Exp Hematol. 2017 Jun;50:46-52. doi: 10.1016/j.exphem.2017.02.003. Epub 2017 Feb 24. Exp Hematol. 2017. PMID: 28238805 Free PMC article.
Fetal Hemoglobin Induction by Epigenetic Drugs.
Lavelle D, Engel JD, Saunthararajah Y. Lavelle D, et al. Semin Hematol. 2018 Apr;55(2):60-67. doi: 10.1053/j.seminhematol.2018.04.008. Epub 2018 Apr 22. Semin Hematol. 2018. PMID: 29958562 Free PMC article. Review.
94 results