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A validation of the application of D(2)O stable isotope tracer techniques for monitoring day-to-day changes in muscle protein subfraction synthesis in humans.
Wilkinson DJ, Franchi MV, Brook MS, Narici MV, Williams JP, Mitchell WK, Szewczyk NJ, Greenhaff PL, Atherton PJ, Smith K. Wilkinson DJ, et al. Among authors: brook ms. Am J Physiol Endocrinol Metab. 2014 Mar 1;306(5):E571-9. doi: 10.1152/ajpendo.00650.2013. Epub 2013 Dec 31. Am J Physiol Endocrinol Metab. 2014. PMID: 24381002 Free PMC article.
Skeletal muscle hypertrophy adaptations predominate in the early stages of resistance exercise training, matching deuterium oxide-derived measures of muscle protein synthesis and mechanistic target of rapamycin complex 1 signaling.
Brook MS, Wilkinson DJ, Mitchell WK, Lund JN, Szewczyk NJ, Greenhaff PL, Smith K, Atherton PJ. Brook MS, et al. FASEB J. 2015 Nov;29(11):4485-96. doi: 10.1096/fj.15-273755. Epub 2015 Jul 13. FASEB J. 2015. PMID: 26169934 Clinical Trial.
A novel D2O tracer method to quantify RNA turnover as a biomarker of de novo ribosomal biogenesis, in vitro, in animal models, and in human skeletal muscle.
Brook MS, Wilkinson DJ, Mitchell WK, Lund JL, Phillips BE, Szewczyk NJ, Kainulainen H, Lensu S, Koch LG, Britton SL, Greenhaff PL, Smith K, Atherton PJ. Brook MS, et al. Am J Physiol Endocrinol Metab. 2017 Dec 1;313(6):E681-E689. doi: 10.1152/ajpendo.00157.2017. Epub 2017 Aug 15. Am J Physiol Endocrinol Metab. 2017. PMID: 28811296 Free PMC article.
Effects of leucine-enriched essential amino acid and whey protein bolus dosing upon skeletal muscle protein synthesis at rest and after exercise in older women.
Wilkinson DJ, Bukhari SSI, Phillips BE, Limb MC, Cegielski J, Brook MS, Rankin D, Mitchell WK, Kobayashi H, Williams JP, Lund J, Greenhaff PL, Smith K, Atherton PJ. Wilkinson DJ, et al. Among authors: brook ms. Clin Nutr. 2018 Dec;37(6 Pt A):2011-2021. doi: 10.1016/j.clnu.2017.09.008. Epub 2017 Sep 23. Clin Nutr. 2018. PMID: 29031484 Free PMC article.
57 results