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Page 1
CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL.
Hagner PR, Man HW, Fontanillo C, Wang M, Couto S, Breider M, Bjorklund C, Havens CG, Lu G, Rychak E, Raymon H, Narla RK, Barnes L, Khambatta G, Chiu H, Kosek J, Kang J, Amantangelo MD, Waldman M, Lopez-Girona A, Cai T, Pourdehnad M, Trotter M, Daniel TO, Schafer PH, Klippel A, Thakurta A, Chopra R, Gandhi AK. Hagner PR, et al. Among authors: klippel a. Blood. 2015 Aug 6;126(6):779-89. doi: 10.1182/blood-2015-02-628669. Epub 2015 May 22. Blood. 2015. PMID: 26002965 Free PMC article. Clinical Trial.
Rate of CRL4(CRBN) substrate Ikaros and Aiolos degradation underlies differential activity of lenalidomide and pomalidomide in multiple myeloma cells by regulation of c-Myc and IRF4.
Bjorklund CC, Lu L, Kang J, Hagner PR, Havens CG, Amatangelo M, Wang M, Ren Y, Couto S, Breider M, Ning Y, Gandhi AK, Daniel TO, Chopra R, Klippel A, Thakurta AG. Bjorklund CC, et al. Among authors: klippel a. Blood Cancer J. 2015 Oct 2;5(10):e354. doi: 10.1038/bcj.2015.66. Blood Cancer J. 2015. PMID: 26430725 Free PMC article.
Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.).
Gandhi AK, Kang J, Havens CG, Conklin T, Ning Y, Wu L, Ito T, Ando H, Waldman MF, Thakurta A, Klippel A, Handa H, Daniel TO, Schafer PH, Chopra R. Gandhi AK, et al. Among authors: klippel a. Br J Haematol. 2014 Mar;164(6):811-21. doi: 10.1111/bjh.12708. Epub 2013 Dec 13. Br J Haematol. 2014. PMID: 24328678 Free PMC article.
Leishmania mexicana N-Acetyltransferease 10 Is Important for Polysome Formation and Cell Cycle Progression.
Maran SR, Leite AB, Alves GG, Bonifácio BS, Alves CE, Moreira POL, Panessa GM, Prado HMDA, Klippel AH, Cussiol JR, Massirer KB, Ferreira TR, Sacks D, Barbiéri CL, Silva MSD, Monte-Neto RLD, Silvio Moretti N. Maran SR, et al. Among authors: klippel ah. Mol Microbiol. 2025 Jan;123(1):60-74. doi: 10.1111/mmi.15338. Epub 2025 Jan 4. Mol Microbiol. 2025. PMID: 39755945
Imlunestrant is an Oral, Brain-Penetrant Selective Estrogen Receptor Degrader with Potent Antitumor Activity in ESR1 Wildtype and Mutant Breast Cancer.
Bhagwat SV, Mur C, Vandekopple M, Zhao B, Shen W, Marugán C, Capen A, Kindler L, Stephens JR, Huber L, Castanares MA, Garcia-Tapia D, Cohen JD, Bastian J, Mattioni B, Yuen E, Baker TK, Rodriguez Cruz V, Fei D, Manro JR, Pulliam N, Dowless MS, Ortiz Ruiz MJ, Yu C, Puca L, Klippel A, Bacchion F, Ismail-Khan R, Rodrik-Outmezguine V, Peng SB, Lallena MJ, Gong X, de Dios A. Bhagwat SV, et al. Among authors: klippel a. Cancer Res. 2024 Dec 9. doi: 10.1158/0008-5472.CAN-24-2608. Online ahead of print. Cancer Res. 2024. PMID: 39652577
The temporal association between social isolation, distress, and psychotic experiences in individuals at clinical high-risk for psychosis.
Akcaoglu Z, Vaessen T, Velthorst E, Lafit G, Achterhof R, Nelson B, McGorry P, Schirmbeck F; EU-GEI High Risk Study; Morgan C, Hartmann J, van der Gaag M, de Haan L, Valmaggia L, McGuire P, Kempton M, Steinhart H, Klippel A, Viechtbauer W, Batink T, van Winkel R, van Amelsvoort T, Marcelis M, van Aubel E, Reininghaus U, Myin-Germeys I. Akcaoglu Z, et al. Among authors: klippel a. Psychol Med. 2024 Jun;54(8):1684-1692. doi: 10.1017/S0033291723003598. Epub 2024 Jan 5. Psychol Med. 2024. PMID: 38179659
Identification of inhibitors for the transmembrane Trypanosoma cruzi eIF2α kinase relevant for parasite proliferation.
Marcelino TP, Fala AM, da Silva MM, Souza-Melo N, Malvezzi AM, Klippel AH, Zoltner M, Padilla-Mejia N, Kosto S, Field MC, Burle-Caldas GA, Teixeira SMR, Couñago RM, Massirer KB, Schenkman S. Marcelino TP, et al. Among authors: klippel ah. J Biol Chem. 2023 Jul;299(7):104857. doi: 10.1016/j.jbc.2023.104857. Epub 2023 May 23. J Biol Chem. 2023. PMID: 37230387 Free PMC article.
Geographic information science in the era of geospatial big data: A cyberspace perspective.
Liu X, Chen M, Claramunt C, Batty M, Kwan MP, Senousi AM, Cheng T, Strobl J, Arzu C, Wilson J, Bandrova T, Konecny M, Torrens PM, Zhang F, He L, Wang J, Ratti C, Kolditz O, Klippel A, Li S, Lin H, Lü G. Liu X, et al. Among authors: klippel a. Innovation (Camb). 2022 Jul 6;3(5):100279. doi: 10.1016/j.xinn.2022.100279. eCollection 2022 Sep 13. Innovation (Camb). 2022. PMID: 35967836 Free PMC article. No abstract available.
98 results