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Page 1
Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective.
Cherepanova OA, Gomez D, Shankman LS, Swiatlowska P, Williams J, Sarmento OF, Alencar GF, Hess DL, Bevard MH, Greene ES, Murgai M, Turner SD, Geng YJ, Bekiranov S, Connelly JJ, Tomilin A, Owens GK. Cherepanova OA, et al. Among authors: alencar gf. Nat Med. 2016 Jun;22(6):657-65. doi: 10.1038/nm.4109. Epub 2016 May 16. Nat Med. 2016. PMID: 27183216 Free PMC article.
Smooth muscle cell-specific deletion of Col15a1 unexpectedly leads to impaired development of advanced atherosclerotic lesions.
Durgin BG, Cherepanova OA, Gomez D, Karaoli T, Alencar GF, Butcher JT, Zhou YQ, Bendeck MP, Isakson BE, Owens GK, Connelly JJ. Durgin BG, et al. Among authors: alencar gf. Am J Physiol Heart Circ Physiol. 2017 May 1;312(5):H943-H958. doi: 10.1152/ajpheart.00029.2017. Epub 2017 Mar 10. Am J Physiol Heart Circ Physiol. 2017. PMID: 28283548 Free PMC article.
Klf4 has an unexpected protective role in perivascular cells within the microvasculature.
Haskins RM, Nguyen AT, Alencar GF, Billaud M, Kelly-Goss MR, Good ME, Bottermann K, Klibanov AL, French BA, Harris TE, Peirce SM, Isakson BE, Owens GK. Haskins RM, et al. Among authors: alencar gf. Am J Physiol Heart Circ Physiol. 2018 Aug 1;315(2):H402-H414. doi: 10.1152/ajpheart.00084.2018. Epub 2018 Apr 6. Am J Physiol Heart Circ Physiol. 2018. PMID: 29631369 Free PMC article.
Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice.
Gomez D, Baylis RA, Durgin BG, Newman AAC, Alencar GF, Mahan S, St Hilaire C, Müller W, Waisman A, Francis SE, Pinteaux E, Randolph GJ, Gram H, Owens GK. Gomez D, et al. Among authors: alencar gf. Nat Med. 2018 Sep;24(9):1418-1429. doi: 10.1038/s41591-018-0124-5. Epub 2018 Jul 23. Nat Med. 2018. PMID: 30038218 Free PMC article.
Revealing the Origins of Foam Cells in Atherosclerotic Lesions.
Owsiany KM, Alencar GF, Owens GK. Owsiany KM, et al. Among authors: alencar gf. Arterioscler Thromb Vasc Biol. 2019 May;39(5):836-838. doi: 10.1161/ATVBAHA.119.312557. Arterioscler Thromb Vasc Biol. 2019. PMID: 31017823 Free PMC article. No abstract available.
Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis.
Alencar GF, Owsiany KM, Karnewar S, Sukhavasi K, Mocci G, Nguyen AT, Williams CM, Shamsuzzaman S, Mokry M, Henderson CA, Haskins R, Baylis RA, Finn AV, McNamara CA, Zunder ER, Venkata V, Pasterkamp G, Björkegren J, Bekiranov S, Owens GK. Alencar GF, et al. Circulation. 2020 Nov 24;142(21):2045-2059. doi: 10.1161/CIRCULATIONAHA.120.046672. Epub 2020 Jul 17. Circulation. 2020. PMID: 32674599 Free PMC article.
Genetic Regulation of Atherosclerosis-Relevant Phenotypes in Human Vascular Smooth Muscle Cells.
Aherrahrou R, Guo L, Nagraj VP, Aguhob A, Hinkle J, Chen L, Yuhl Soh J, Lue D, Alencar GF, Boltjes A, van der Laan SW, Farber E, Fuller D, Anane-Wae R, Akingbesote N, Manichaikul AW, Ma L, Kaikkonen MU, Björkegren JLM, Önengüt-Gümüşcü S, Pasterkamp G, Miller CL, Owens GK, Finn A, Navab M, Fogelman AM, Berliner JA, Civelek M. Aherrahrou R, et al. Among authors: alencar gf. Circ Res. 2020 Dec 4;127(12):1552-1565. doi: 10.1161/CIRCRESAHA.120.317415. Epub 2020 Oct 12. Circ Res. 2020. PMID: 33040646 Free PMC article.
KLF4 (Kruppel-Like Factor 4)-Dependent Perivascular Plasticity Contributes to Adipose Tissue inflammation.
Bulut GB, Alencar GF, Owsiany KM, Nguyen AT, Karnewar S, Haskins RM, Waller LK, Cherepanova OA, Deaton RA, Shankman LS, Keller SR, Owens GK. Bulut GB, et al. Among authors: alencar gf. Arterioscler Thromb Vasc Biol. 2021 Jan;41(1):284-301. doi: 10.1161/ATVBAHA.120.314703. Epub 2020 Oct 15. Arterioscler Thromb Vasc Biol. 2021. PMID: 33054397 Free PMC article.
18 results