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RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E).
Poulikakos PI, Persaud Y, Janakiraman M, Kong X, Ng C, Moriceau G, Shi H, Atefi M, Titz B, Gabay MT, Salton M, Dahlman KB, Tadi M, Wargo JA, Flaherty KT, Kelley MC, Misteli T, Chapman PB, Sosman JA, Graeber TG, Ribas A, Lo RS, Rosen N, Solit DB. Poulikakos PI, et al. Nature. 2011 Nov 23;480(7377):387-90. doi: 10.1038/nature10662. Nature. 2011. PMID: 22113612 Free PMC article.
New perspectives for targeting RAF kinase in human cancer.
Karoulia Z, Gavathiotis E, Poulikakos PI. Karoulia Z, et al. Among authors: poulikakos pi. Nat Rev Cancer. 2017 Nov;17(11):676-691. doi: 10.1038/nrc.2017.79. Epub 2017 Oct 6. Nat Rev Cancer. 2017. PMID: 28984291 Free PMC article. Review.
Inhibitors of BRAF dimers using an allosteric site.
Cotto-Rios XM, Agianian B, Gitego N, Zacharioudakis E, Giricz O, Wu Y, Zou Y, Verma A, Poulikakos PI, Gavathiotis E. Cotto-Rios XM, et al. Among authors: poulikakos pi. Nat Commun. 2020 Sep 1;11(1):4370. doi: 10.1038/s41467-020-18123-2. Nat Commun. 2020. PMID: 32873792 Free PMC article.
BRAFV600E-induced senescence drives Langerhans cell histiocytosis pathophysiology.
Bigenwald C, Le Berichel J, Wilk CM, Chakraborty R, Chen ST, Tabachnikova A, Mancusi R, Abhyankar H, Casanova-Acebes M, Laface I, Akturk G, Jobson J, Karoulia Z, Martin JC, Grout J, Rafiei A, Lin H, Manz MG, Baccarini A, Poulikakos PI, Brown BD, Gnjatic S, Lujambio A, McClain KL, Picarsic J, Allen CE, Merad M. Bigenwald C, et al. Among authors: poulikakos pi. Nat Med. 2021 May;27(5):851-861. doi: 10.1038/s41591-021-01304-x. Epub 2021 May 6. Nat Med. 2021. PMID: 33958797 Free PMC article.
Mutant BRAF melanomas--dependence and resistance.
Poulikakos PI, Rosen N. Poulikakos PI, et al. Cancer Cell. 2011 Jan 18;19(1):11-5. doi: 10.1016/j.ccr.2011.01.008. Cancer Cell. 2011. PMID: 21251612 Free article. Review.
Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas.
Lito P, Pratilas CA, Joseph EW, Tadi M, Halilovic E, Zubrowski M, Huang A, Wong WL, Callahan MK, Merghoub T, Wolchok JD, de Stanchina E, Chandarlapaty S, Poulikakos PI, Fagin JA, Rosen N. Lito P, et al. Among authors: poulikakos pi. Cancer Cell. 2012 Nov 13;22(5):668-82. doi: 10.1016/j.ccr.2012.10.009. Cancer Cell. 2012. PMID: 23153539 Free PMC article.
44 results