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A chimeric protein comprising the glucosyltransferase and cysteine proteinase domains of toxin B and the receptor binding domain of toxin A induces protective immunity against Clostridium difficile infection in mice and hamsters.
Wang YK, Yan YX, Kim HB, Ju X, Zhao S, Zhang K, Tzipori S, Sun X. Wang YK, et al. Among authors: sun x. Hum Vaccin Immunother. 2015;11(9):2215-22. doi: 10.1080/21645515.2015.1052352. Epub 2015 Jun 2. Hum Vaccin Immunother. 2015. PMID: 26036797 Free PMC article.
Oral Immunization with Nontoxigenic Clostridium difficile Strains Expressing Chimeric Fragments of TcdA and TcdB Elicits Protective Immunity against C. difficile Infection in Both Mice and Hamsters.
Wang Y, Wang S, Bouillaut L, Li C, Duan Z, Zhang K, Ju X, Tzipori S, Sonenshein AL, Sun X. Wang Y, et al. Among authors: sun x. Infect Immun. 2018 Oct 25;86(11):e00489-18. doi: 10.1128/IAI.00489-18. Print 2018 Nov. Infect Immun. 2018. PMID: 30150259 Free PMC article.
The enterotoxicity of Clostridium difficile toxins.
Sun X, Savidge T, Feng H. Sun X, et al. Toxins (Basel). 2010 Jul;2(7):1848-80. doi: 10.3390/toxins2071848. Epub 2010 Jul 14. Toxins (Basel). 2010. PMID: 22069662 Free PMC article. Review.
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