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GIRK3 gates activation of the mesolimbic dopaminergic pathway by ethanol.
Herman MA, Sidhu H, Stouffer DG, Kreifeldt M, Le D, Cates-Gatto C, Munoz MB, Roberts AJ, Parsons LH, Roberto M, Wickman K, Slesinger PA, Contet C. Herman MA, et al. Among authors: slesinger pa. Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):7091-6. doi: 10.1073/pnas.1416146112. Epub 2015 May 11. Proc Natl Acad Sci U S A. 2015. PMID: 25964320 Free PMC article.
Invasion of glioma cells through confined space requires membrane tension regulation and mechano-electrical coupling via Plexin-B2.
Junqueira Alves C, Hannah T, Sadia S, Kolsteeg C, Dixon A, Wiener RJ, Nguyen H, Tipping MJ, Ladeira JS, Franklin PFDC, Dutra de Nigro NP, Dias RA, Zabala Capriles PV, Rodrigues Furtado de Mendonça JP, Slesinger P, Costa K, Zou H, Friedel RH. Junqueira Alves C, et al. bioRxiv [Preprint]. 2024 Jan 2:2024.01.02.573660. doi: 10.1101/2024.01.02.573660. bioRxiv. 2024. Update in: Nat Commun. 2025 Jan 2;16(1):272. doi: 10.1038/s41467-024-55056-6 PMID: 38313256 Free PMC article. Updated. Preprint.
Upregulated GIRK2 counteracts ethanol-induced changes in excitability & respiration in human neurons.
Prytkova I, Liu Y, Fernando M, Gameiro-Ros I, Popova D, Kamarajan C, Xuei X, Chorlian DB, Edenberg HJ, Tischfield JA, Porjesz B, Pang ZP, Hart RP, Goate A, Slesinger PA. Prytkova I, et al. Among authors: slesinger pa. bioRxiv [Preprint]. 2024 Jan 13:2023.03.22.533236. doi: 10.1101/2023.03.22.533236. bioRxiv. 2024. Update in: J Neurosci. 2024 Apr 17;44(16):e0918232024. doi: 10.1523/JNEUROSCI.0918-23.2024 PMID: 36993693 Free PMC article. Updated. Preprint.
A discrete alcohol pocket involved in GIRK channel activation.
Aryal P, Dvir H, Choe S, Slesinger PA. Aryal P, et al. Among authors: slesinger pa. Nat Neurosci. 2009 Aug;12(8):988-95. doi: 10.1038/nn.2358. Epub 2009 Jun 28. Nat Neurosci. 2009. PMID: 19561601 Free PMC article.
116 results