Augustijns P - Search Results

1

Verapamil hepatic clearance in four preclinical rat models: towards activity-based scaling.

Nicolaï J, De Bruyn T, Van Veldhoven PP, Keemink J, Augustijns P, Annaert P. Nicolaï J, et al. Among authors: augustijns p. Biopharm Drug Dispos. 2015 Oct;36(7):462-80. doi: 10.1002/bdd.1959. Epub 2015 Jun 11. Biopharm Drug Dispos. 2015. PMID: 25963583

2

Transport, uptake, and metabolism of the bis(pivaloyloxymethyl)-ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine in an in vitro cell culture system of the intestinal mucosa (Caco-2).

Annaert P, Kinget R, Naesens L, de Clercq E, Augustijns P. Annaert P, et al. Among authors: augustijns p. Pharm Res. 1997 Apr;14(4):492-6. doi: 10.1023/a:1012155717819. Pharm Res. 1997. PMID: 9144737

3

Antiretroviral efficacy and pharmacokinetics of oral bis(isopropyloxycarbonyloxymethyl)-9-(2-phosphonylmethoxypropyl)adenine in mice.

Naesens L, Bischofberger N, Augustijns P, Annaert P, Van den Mooter G, Arimilli MN, Kim CU, De Clercq E. Naesens L, et al. Among authors: augustijns p. Antimicrob Agents Chemother. 1998 Jul;42(7):1568-73. doi: 10.1128/AAC.42.7.1568. Antimicrob Agents Chemother. 1998. PMID: 9660984 Free PMC article.

4

Carrier mechanisms involved in the transepithelial transport of bis(POM)-PMEA and its metabolites across Caco-2 monolayers.

Annaert P, Van Gelder J, Naesens L, De Clercq E, Van den Mooter G, Kinget R, Augustijns P. Annaert P, et al. Among authors: augustijns p. Pharm Res. 1998 Aug;15(8):1168-73. doi: 10.1023/a:1011923420719. Pharm Res. 1998. PMID: 9706045

5

Inhibition of intestinal metabolism of the antiviral ester prodrug bis(POC)-PMPA by nature-identical fruit extracts as a strategy to enhance its oral absorption: an in vitro study.

Van Gelder J, Annaert P, Naesens L, De Clercq E, Van den Mooter G, Kinget R, Augustijns P. Van Gelder J, et al. Among authors: augustijns p. Pharm Res. 1999 Jul;16(7):1035-40. doi: 10.1023/a:1018931631912. Pharm Res. 1999. PMID: 10450927

6

Evaluation of the potential of ion pair formation to improve the oral absorption of two potent antiviral compounds, AMD3100 and PMPA.

Van Gelder J, Witvrouw M, Pannecouque C, Henson G, Bridger G, Naesens L, De Clercq E, Annaert P, Shafiee M, Van den Mooter G, Kinget R, Augustijns P. Van Gelder J, et al. Among authors: augustijns p. Int J Pharm. 1999 Sep 20;186(2):127-36. doi: 10.1016/s0378-5173(99)00150-7. Int J Pharm. 1999. PMID: 10486430

7

In vitro, ex vivo, and in situ intestinal absorption characteristics of the antiviral ester prodrug adefovir dipivoxil.

Annaert P, Tukker JJ, van Gelder J, Naesens L, de Clercq E, van Den Mooter G, Kinget R, Augustijns P. Annaert P, et al. Among authors: augustijns p. J Pharm Sci. 2000 Aug;89(8):1054-62. doi: 10.1002/1520-6017(200008)89:8<1054::aid-jps10>3.0.co;2-5. J Pharm Sci. 2000. PMID: 10906729

8

Increased absorption of the antiviral ester prodrug tenofovir disoproxil in rat ileum by inhibiting its intestinal metabolism.

Van Gelder J, Deferme S, Annaert P, Naesens L, De Clercq E, Van den Mooter G, Kinget R, Augustijns P. Van Gelder J, et al. Among authors: augustijns p. Drug Metab Dispos. 2000 Dec;28(12):1394-6. Drug Metab Dispos. 2000. PMID: 11095573

9

Increasing the oral bioavailability of the poorly water soluble drug itraconazole with ordered mesoporous silica.

Mellaerts R, Mols R, Jammaer JA, Aerts CA, Annaert P, Van Humbeeck J, Van den Mooter G, Augustijns P, Martens JA. Mellaerts R, et al. Among authors: augustijns p. Eur J Pharm Biopharm. 2008 May;69(1):223-30. doi: 10.1016/j.ejpb.2007.11.006. Epub 2007 Nov 23. Eur J Pharm Biopharm. 2008. PMID: 18164930

10

Ordered mesoporous silica induces pH-independent supersaturation of the basic low solubility compound itraconazole resulting in enhanced transepithelial transport.

Mellaerts R, Mols R, Kayaert P, Annaert P, Van Humbeeck J, Van den Mooter G, Martens JA, Augustijns P. Mellaerts R, et al. Among authors: augustijns p. Int J Pharm. 2008 Jun 5;357(1-2):169-79. doi: 10.1016/j.ijpharm.2008.01.049. Epub 2008 Feb 3. Int J Pharm. 2008. PMID: 18325700

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