Jiang F - Search Results

1

Novel natural-product-like caged xanthones with improved druglike properties and in vivo antitumor potency.

Wu Y, Hu M, Yang L, Li X, Bian J, Jiang F, Sun H, You Q, Zhang X. Wu Y, et al. Among authors: jiang f. Bioorg Med Chem Lett. 2015 Jun 15;25(12):2584-8. doi: 10.1016/j.bmcl.2015.04.031. Epub 2015 Apr 18. Bioorg Med Chem Lett. 2015. PMID: 25958244

2

Synthesis and evaluation of a novel class Hsp90 inhibitors containing 1-phenylpiperazine scaffold.

Jia JM, Liu F, Xu XL, Guo XK, Jiang F, Cherfaoui B, Sun HP, You QD. Jia JM, et al. Among authors: jiang f. Bioorg Med Chem Lett. 2014 Mar 15;24(6):1557-61. doi: 10.1016/j.bmcl.2014.01.070. Epub 2014 Feb 15. Bioorg Med Chem Lett. 2014. PMID: 24582477

3

Identification and optimization of novel Hsp90 inhibitors with tetrahydropyrido[4,3-d]pyrimidines core through shape-based screening.

Sun HP, Jia JM, Jiang F, Xu XL, Liu F, Guo XK, Cherfaoui B, Huang HZ, Pan Y, You QD. Sun HP, et al. Among authors: jiang f. Eur J Med Chem. 2014 May 22;79:399-412. doi: 10.1016/j.ejmech.2014.03.061. Epub 2014 Mar 21. Eur J Med Chem. 2014. PMID: 24763261

4

Structure-based design and synthesis of small molecular inhibitors disturbing the interaction of MLL1-WDR5.

Li DD, Chen WL, Xu XL, Jiang F, Wang L, Xie YY, Zhang XJ, Guo XK, You QD, Sun HP. Li DD, et al. Among authors: jiang f. Eur J Med Chem. 2016 Aug 8;118:1-8. doi: 10.1016/j.ejmech.2016.04.032. Epub 2016 Apr 13. Eur J Med Chem. 2016. PMID: 27116709

5

Synthesis and evaluation of 4-(2-hydroxypropyl)piperazin-1-yl) derivatives as Hsp90 inhibitors.

Cherfaoui B, Guo TK, Sun HP, Cheng WL, Liu F, Jiang F, Xu XL, You QD. Cherfaoui B, et al. Among authors: jiang f. Bioorg Med Chem. 2016 Jun 1;24(11):2423-2432. doi: 10.1016/j.bmc.2016.03.049. Epub 2016 Apr 7. Bioorg Med Chem. 2016. PMID: 27134115

6

Hybrids of the Benzofuran Core from Natural Products and the 2,4-Dihydroxy-5-isopropylbenzene Fragment as Potent Hsp90 Inhibitors: Design, Synthesis and Bioevaluation.

Jia JM, Liu F, Xu XL, Guo XK, Jiang F, Huang HZ, Pan Y, Cherfaoui B, Sun HP, You QD. Jia JM, et al. Among authors: jiang f. Mol Inform. 2014 Aug;33(8):495-502. doi: 10.1002/minf.201300182. Epub 2014 Jul 2. Mol Inform. 2014. PMID: 27486036

7

Optimization and biological evaluation of celastrol derivatives as Hsp90-Cdc37 interaction disruptors with improved druglike properties.

Jiang F, Wang HJ, Bao QC, Wang L, Jin YH, Zhang Q, Jiang D, You QD, Xu XL. Jiang F, et al. Among authors: jiang d. Bioorg Med Chem. 2016 Nov 1;24(21):5431-5439. doi: 10.1016/j.bmc.2016.08.070. Epub 2016 Sep 1. Bioorg Med Chem. 2016. PMID: 27647369

8

Novel Tetrahydropyrido[4,3-d]pyrimidines as Potent Inhibitors of Chaperone Heat Shock Protein 90.

Jiang F, Wang HJ, Jin YH, Zhang Q, Wang ZH, Jia JM, Liu F, Wang L, Bao QC, Li DD, You QD, Xu XL. Jiang F, et al. J Med Chem. 2016 Dec 8;59(23):10498-10519. doi: 10.1021/acs.jmedchem.6b00912. Epub 2016 Nov 22. J Med Chem. 2016. PMID: 27933959

9

Identification and optimization of novel 6-acylamino-2-aminoquinolines as potent Hsp90 C-terminal inhibitors.

Jiang F, Guo AP, Xu JC, Wang HJ, Mo XF, You QD, Xu XL. Jiang F, et al. Eur J Med Chem. 2017 Dec 1;141:1-14. doi: 10.1016/j.ejmech.2017.07.080. Epub 2017 Aug 2. Eur J Med Chem. 2017. PMID: 29028527

10

Discovery of a Potent Grp94 Selective Inhibitor with Anti-Inflammatory Efficacy in a Mouse Model of Ulcerative Colitis.

Jiang F, Guo AP, Xu JC, You QD, Xu XL. Jiang F, et al. J Med Chem. 2018 Nov 8;61(21):9513-9533. doi: 10.1021/acs.jmedchem.8b00800. Epub 2018 Oct 26. J Med Chem. 2018. PMID: 30351001

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