Fryer RM - Search Results

1

Long-term stability, reproducibility, and statistical sensitivity of a telemetry-instrumented dog model: A 27-month longitudinal assessment.

Fryer RM, Ng KJ, Chi L, Jin X, Reinhart GA. Fryer RM, et al. J Pharmacol Toxicol Methods. 2015 Jul-Aug;74:26-32. doi: 10.1016/j.vascn.2015.04.007. Epub 2015 May 3. J Pharmacol Toxicol Methods. 2015. PMID: 25946685

2

Functional biomarkers of musculoskeletal syndrome (MSS) for early in vivo screening of selective MMP-13 inhibitors.

Mazurek SG, Li J, Nabozny GH, Reinhart GA, Muthukumarana AC, Harrison PC, Fryer RM. Mazurek SG, et al. Among authors: fryer rm. J Pharmacol Toxicol Methods. 2011 Jul-Aug;64(1):89-96. doi: 10.1016/j.vascn.2011.02.002. Epub 2011 Mar 2. J Pharmacol Toxicol Methods. 2011. PMID: 21376127

3

Strategic integration of in vivo cardiovascular models during lead optimization: predictive value of 4 models independent of species, route of administration, and influence of anesthesia.

Fryer RM, Harrison PC, Muthukumarana A, Nodop Mazurek SG, Ng KJ, Chen RR, Harrington KE, Dinallo RM, Chi L, Reinhart GA. Fryer RM, et al. J Cardiovasc Pharmacol. 2012 Apr;59(4):369-76. doi: 10.1097/FJC.0b013e31824485dd. J Cardiovasc Pharmacol. 2012. PMID: 22179024

4

Blood pressure regulation by ETA and ETB receptors in conscious, telemetry-instrumented mice and role of ETA in hypertension produced by selective ETB blockade.

Fryer RM, Rakestraw PA, Banfor PN, Cox BF, Opgenorth TJ, Reinhart GA. Fryer RM, et al. Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2554-9. doi: 10.1152/ajpheart.01221.2005. Epub 2006 Jan 6. Am J Physiol Heart Circ Physiol. 2006. PMID: 16399858 Free article.

5

Mitigation of off-target adrenergic binding and effects on cardiovascular function in the discovery of novel ribosomal S6 kinase 2 inhibitors.

Fryer RM, Muthukumarana A, Chen RR, Smith JD, Mazurek SN, Harrington KE, Dinallo RM, Burke J, DiCapua FM, Guo X, Kirrane TM, Snow RJ, Zhang Y, Soleymanzadeh F, Madwed JB, Kashem MA, Kugler SZ, O'Neill MM, Harrison PC, Reinhart GA, Boyer SJ. Fryer RM, et al. J Pharmacol Exp Ther. 2012 Mar;340(3):492-500. doi: 10.1124/jpet.111.189365. Epub 2011 Nov 29. J Pharmacol Exp Ther. 2012. PMID: 22128344

6

Quantification and Comparison of Anti-Fibrotic Therapies by Polarized SRM and SHG-Based Morphometry in Rat UUO Model.

Qian HS, Weldon SM, Matera D, Lee C, Yang H, Fryer RM, Fogo AB, Reinhart GA. Qian HS, et al. Among authors: fryer rm. PLoS One. 2016 Jun 3;11(6):e0156734. doi: 10.1371/journal.pone.0156734. eCollection 2016. PLoS One. 2016. PMID: 27257917 Free PMC article.

7

Cardiovascular safety pharmacology studies in dogs enabled for a poorly soluble molecule using spray-dried dispersion: Impact on lead selection.

Tseng YC, Linehan B, Ng KJ, Smith DM, Markert M, Patel M, Guth B, Fryer RM. Tseng YC, et al. Among authors: fryer rm. Int J Pharm. 2016 Oct 15;512(1):137-146. doi: 10.1016/j.ijpharm.2016.08.028. Epub 2016 Aug 16. Int J Pharm. 2016. PMID: 27543349

8

(-)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637), a novel ATP-sensitive potassium channel opener: hemodynamic comparison to ZD-6169, WAY-133537, and nifedipine in the anesthetized canine.

Fryer RM, Preusser LC, Calzadilla SV, Hu Y, Xu H, Marsh KC, Cox BF, Lin CT, Gopalakrishnan M, Reinhart GA. Fryer RM, et al. J Cardiovasc Pharmacol. 2004 Aug;44(2):137-47. doi: 10.1097/00005344-200408000-00001. J Cardiovasc Pharmacol. 2004. PMID: 15243293

9

Pharmacological characterization of the novel dihydropyridine potassium channel opener, (9R)-9-(3-iodo-4-methylphenyl)-5,9-dihydro-3H-furo[3,4-b]pyrano[4,3-e]pyridine-1,8(4H,7H)-dione (A-325100), and the regulation of cardiovascular function in conscious and anesthetized beagle dogs.

Fryer RM, Rakestraw PA, Preusser LC, Brune ME, Carroll WA, Buckner SA, Shieh CC, King LL, Marsh KC, Gopalakrishnan M, Cox BF, Reinhart GA. Fryer RM, et al. J Cardiovasc Pharmacol. 2005 Aug;46(2):232-40. doi: 10.1097/01.fjc.0000171755.28317.85. J Cardiovasc Pharmacol. 2005. PMID: 16044036

10

Differential inhibition of renin mRNA expression by paricalcitol and calcitriol in C57/BL6 mice.

Fryer RM, Rakestraw PA, Nakane M, Dixon D, Banfor PN, Koch KA, Wu-Wong JR, Reinhart GA. Fryer RM, et al. Nephron Physiol. 2007;106(4):p76-81. doi: 10.1159/000104875. Epub 2007 Jul 2. Nephron Physiol. 2007. PMID: 17622742

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